依据病原菌耐药性分析合理使用抗菌药物  

Based on Analysis of Antimicrobial Resistance in Clinical Rationalization Proposals

作　　者：刘渝[1] 吴寅[1] 王靖雯[1] 王志睿[1] 冯娟[1] 朱彦荣[1] 文爱东[1] 

机构地区：[1]第四军医大学附属西京医院药剂科,陕西西安710032

出　　处：《中华医院感染学杂志》2010年第4期536-538,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究分析引起医院感染的主要病原菌及耐药性,为合理使用抗菌药物、有效控制医院感染提供依据。方法利用Excel软件对医院2008年临床标本培养的3532株病原菌进行统计分析。结果病原菌以大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌等为主;其中肠杆菌科细菌占30.52%,非发酵糖菌占25.42%,革兰阳性球菌占24.32%,真菌占15.37%;大肠埃希菌中产ESBLs占71.53%,肺炎克雷伯菌中产ESBLs占66.06%,金黄色葡萄球菌中MRSA占57.05%。结论细菌耐药是当前临床面临的一个十分严峻问题,临床应根据病原菌流行特征合理使用抗菌药物。OBJECTIVE To analyze the hospital infection caused by pathogenic bacteria and drug resistance for the antimicrobial agents, and effectively provide a basis to control hospital infection. METHODS The Microsoft Excel was used for statistical analysis of pathogenic bacteria from the 3532 clinical specimens in a hospital in 2008. RESULTS The pathogenic bacteria were Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and others. Enterobacteriaceae accounted for 30. 52%, non-fermentive bacterial for 25.42%, Gram-positive cocci 24.32%, and for fungi were 15.37%. ESBLs-produeing E. coli and K. pneumoniae were 71. 53% and 66. 06%, respectively, 57. 05% of were MRSA. CONCLUSIONS Clinical drug-resistant bacteria have became a serious problem. It can be resolved based on the characteristics of the local pathogen prevalence and antimicrobial resistance analysis, and the correct use of antimicrobials.

关 键 词：抗菌药物 病原菌 耐药性 

分 类 号：R978.1[医药卫生—药品]