甲状腺疾病围手术期抗菌药物使用调查  

Application of Antibiotics in Patients with Thyroid Diseases in Perioperative Period

作　　者：黄琴香[1] 

机构地区：[1]温州医学院附属温岭医院院感科,浙江温岭317500

出　　处：《中华医院感染学杂志》2010年第4期542-543,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解甲状腺疾病围手术期抗菌药物应用情况,为加强抗菌药物的合理使用和规范化管理提供依据。方法对2008年1~12月243例甲状腺手术病例进行回顾性调查,按调查内容分别输入电脑,并对数据进行汇总分析。结果218例围手术期使用抗菌药物,使用率为89.71%,共涉及7大类19种抗菌药物,使用频率最高的是喹诺酮类97例(42.17%),其次是青霉素类/酶抑制剂72例(31.30%);使用时间为1~10 d,平均4.54 d,≤3 d者102例(46.79%),首次用药在术前30 min^2 h 45例(20.64%)、术后171例(78.44%);抗菌药物不合理使用182例(83.49%);发生医院感染共6例,其中手术部位感染2例(0.82%)、下呼吸道感染4例(1.65%)。结论围手术期抗菌药物使用不规范、用药时间长、选药档次高、用药时机不合理等现象,需进一步规范管理,加强培训,加大干预力度,促进抗菌药物的合理使用。OBJECTIVE To study the application situation of antibiotics for patients with thyroid diseases in perioperative period to provide evidence for enhancing the rational use and standardized management of antibiotics. METHODS Totally 243 cases of patients with thyroid diseases from Jan to Dec in 2008 received retrospective investigation. Input into the computer according to the investigation content and take pooled analysis on the data. RESULTS Usage rate of antibiotics in 218 cases in perioperative period was 89.71%. It involved 7 classes, 19 kinds of antibiotics, in which quinolones were the most frequently used （97 cases, 42. 17%）, followed by penicillins/enzyme inhibitor （72 cases, 31.30%）. Using time ranged from 1 to 10 days, the average time was 4.54 days, less than 3 days were in 102 cases （46.79%）. Forty-five cases got first administration 30min before operation （20. 64%）, while 171 cases （78. 44N） after operation. Unreasonable usage appeared in 182 cases （83.49%）. Nosocomial infection appeared in 6 cases, in which 2 cases got surgical site infection （0.82 %） and 4 cases got lower respiratory tract infection （1.65 %）. CONCLUSIONS Usage of antibiotics in perioperative period has the problems of irrational use, shch as long administration time, high grade of choosing drug and unreasonable administration chance. Further standardizing the management, enhancing the training and increasing the intervention are needed to improve the rational use of antibiotics.

关 键 词：甲状腺疾病 围手术期 抗菌药物 医院感染 合理应用 

分 类 号：R978.1[医药卫生—药品]