西藏胡黄连化学成分的分离和鉴定  

Isolation and Identification of a New Compound from the Roots of Picrorhiza Scrophulariiflora

作　　者：尹立子[1] 欧阳萍[1] 徐雪[1] 周丽光[1,2] 王大成[1] 邓旭明[1] 

机构地区：[1]吉林大学畜牧兽医学院,长春130062 [2]吉林省五星动物保健药厂,长春130062

出　　处：《高等学校化学学报》2010年第1期84-87,共4页Chemical Journal of Chinese Universities

基　　金：国家科技支撑计划(批准号:200B6AD31B05;2008BAD4B04-4)资助

摘　　要：从西藏胡黄连中分离和鉴定了4个化合物,其中化合物1是新化合物,命名为西藏胡黄连酚苷E(Scrophenoside E),结构为(2-甲氧基-4-乙酰基)苯酚-3-β-D-吡喃葡萄糖基-6-O-(4-β-D-吡喃葡萄糖基)香草酰基-β-D-吡喃葡萄糖苷.Xizang Huhuanglian, the roots of Picrorhiza scrophulariiflora Pennell, is a traditional Chinese Medicine used to treat damp-heat dysentery, jaundice, indigestion, common fever, acute viral hepatitis, and steaming of bone. The scholars of domestic and foreign have studied on the pharmacological effects of the plant, and found that the plant will be one of the most effective preparation in protecting the liver. This plant is rich in terpenoids, iridoid glycosides, phenolic glycosides and phenylethanoid glycosides. These compounds of the plant were isolated via silica gel column, D101 macroporous column, Sephadex LH-20 column, ODS column chromatography and HPLC. The structures of these compounds were identified by spectroscopic meth- ods（NMR, IR, UV and MS） and chemical methods. Four compounds from this plant were obtained. Their names are Scrophenoside E （ 1 ） [ （ 6-（ 4-acetyl-2-methoxyphenoxy ） -3,5-dihydroxy-4-（ 3,4,5-trihydroxy-6- （ hydroxymethyl ） tetrahydro-2H-pyran-2-yloxy ） tetrahydro-2H-pyran-2-yl ） methyl-3-methoxy4-（ 3,4,5-trihy- droxy-6- （ hydroxymethyl ） tetrahydro-2H-pyran-2-yloxy） benzoate ], Coniferin （ 2 ）, Arbutin （ 3 ） and Androsin （4）. Scrophenoside E is a new compound. Coniferin, Arbutin and Androsin are three known compounds.

关 键 词：西藏胡黄连 苯乙醇苷 西藏胡黄连酚苷E 

分 类 号：O629.9[理学—有机化学]