五倍子、黄芩和黄连联合应用对MRSA的体外抗菌活性研究  

Bacteriostatic Activity of Combined Application of Galla chinensis,Scutellaria baicalensis and Rhizoma coptidis Against MRSA in Vitro

作　　者：任书青[1] 曹德英[2] 杨继章[1] 杨树民[1] 宋永朝[1] 

机构地区：[1]河北医科大学第一医院,石家庄市050031 [2]河北医科大学药学院,石家庄市050017

出　　处：《中国药房》2010年第3期198-199,共2页China Pharmacy

基　　金：河北省医学科学研究重点课题计划(06195)

摘　　要：目的:研究五倍子、黄芩和黄连联合应用对耐甲氧西林金黄色葡萄球菌(MRSA)的体外抗菌活性。方法:采用肉汤稀释法测定其对MRSA的最小抑菌浓度(MIC)值,推算出半数抑菌浓度(MIC50)和抑菌90%浓度(MIC90)值,并作比较。结果:五倍子、黄芩和黄连单药及相互配伍后对MRSA的抑菌效果从高至低依次为:黄芩-五倍子、五倍子、黄连-五倍子、黄连、黄连-黄芩、黄芩。结论:黄芩与五倍子配伍对MRSA有协同作用,与黄芩呈拮抗作用。OBJECTIVE ： To study the bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. METHODS： The MIC of combined application of G.chinensis, S.baicalensis and R. coptidis against MRSA were detected by broth dilution method. The MIC50 and the MI90 were calculated and compared with MIC. RESULTS： S.baicalensis-G.chinensis had the strongest bacteriostatic effect among all compatibility recipe and single recipe, followed by G.chinensis, R.coptidis-G.chinensis, R.coptidis, R. coptidis-S.baicalensis, S.baicalensis. CONCLUSION ： The compatibilities of S. baicalensis and G.chinensis have synergistic action on MRSA. However, bacteriostatic activity of R.coptidis against MRSA is independent from G.chinensis; bacteriostatic activity of R.coptidis against MRSA resists to S.baicalensis.

关 键 词：五倍子 黄芩 黄连 耐甲氧西林金黄色葡萄球菌 最小抑菌浓度 

分 类 号：R285[医药卫生—中药学] R97[医药卫生—中医学]