阿胶低肽不同给药途径的药效学研究  

Pharmacodynamic Study on Different Approaches of Using Low Peptide of E’ jiao

作　　者：付英杰[1] 曲立生[2] 田景振[1] 

机构地区：[1]山东中医药大学药学院,济南市250355 [2]山东泰安市中医医院,泰安市271000

出　　处：《中国药房》2010年第3期217-218,共2页China Pharmacy

摘　　要：目的:研究阿胶低肽不同给药途径的药效学。方法:皮下注射盐酸苯肼复制家兔贫血模型,分别给予模型家兔腹腔注射1～3kD阿胶低肽,灌胃<5kD阿胶低肽,灌胃5%阿胶水溶液,测定给药7d后的血红蛋白(Hb)、红细胞计数(RBC)、白细胞计数(WBC)值。分别给予健康小鼠腹腔注射1～3kD阿胶低肽,灌胃<5kD阿胶低肽,灌胃葡萄糖溶液,给药14d后测定小鼠负重游泳时间。腹腔注射氢化可的松复制免疫低下小鼠模型,分别给予模型小鼠腹腔注射1～3kD阿胶低肽,灌胃<5kD阿胶低肽,灌胃5%阿胶水溶液,给药6d后,测定小鼠脾重指数。结果:对于化学药物所致的贫血,1～3kD阿胶低肽可显著提升Hb,其作用高于<5kD阿胶低肽,但提升RBC和WBC的作用则与阿胶相当;阿胶低肽有抗疲劳作用;阿胶低肽可显著增加模型小鼠脾重指数。结论:阿胶低肽各种给药方式均有一定的免疫增强作用。OBJECTIVE：To study pharmacodynamics of different approaches of using low peptide of E＇ jiao. METHODS： Anemia model rabbits and immunosuppressed model mice were induced by injecting with phenylhydrazine hydrochloride subcutaneously and hydrocortisone via i.p. respectively then treated with low peptide of E＇ jiao （ 1-3 kD） via i.p., low peptide of E＇ jiao of lower than 5 k and 5% E＇ jiao solution via i.g. The values of Hb, RBC, WBC in model rabbits were measured after 7 days of medication and spleen weigh index was detected after 6 days of medication. The healthy mice were treated with low peptide of E＇ jiao （ 1-3 kD） via i.p., low peptide of E＇ jiao of lower than 5 k via i.g. and glucose solution via i.g. Then the load swimming time was determined after 14 days of medication. RESULTS： Chemical medicine-induced anemia was improved by 1-3 kD low peptide of E＇ jiao increasing the amount of Hb. Low peptide of E＇ jiao of lower than 5 k could not produce such an good effect on anemia but was eaqul to oral E＇ jian in increasing the value of RBC, WBC. Low peptide of E＇ jiao was helpful to or had effect on anti-fatigue and remarkably increased spleen index of mice. CONCLUSION： Low peptide of E＇ jiao used by different approaches can strengthen immunity.

关 键 词：阿胶低肽 给药途径 药效学 

分 类 号：R285.5[医药卫生—中药学] R97[医药卫生—中医学]