姜黄素固体分散体对2型糖尿病大鼠氧化应激的影响  

Effect of Curcumin Solid Dispersion on Oxidative Stress in Diabetic Rats

作　　者：张卫国[1] 韩刚[1] 王彬[2] 阎林奇[1] 翟冠钰[1] 范颖[1] 

机构地区：[1]华北煤炭医学院药学系,河北唐山063000 [2]贵州大学生命科学院,贵阳550025

出　　处：《中国现代应用药学》2010年第1期13-15,34,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究姜黄素固体分散体对2型糖尿病大鼠氧化应激的影响。方法以聚乙烯吡咯烷酮(PVP)为载体制备姜黄素固体分散体。大鼠腹腔注射小剂量链脲佐菌素(STZ)建立2型糖尿病模型,随机分成糖尿病模型(MD)组、聚乙烯吡咯烷酮(PVP)组、姜黄素(CU)组、姜黄素固体分散体低剂量(LSD)组、姜黄素固体分散体高剂量(HSD)组。大鼠给药6周后,测定血清及肾脏组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活力,丙二醛(MDA)的含量。结果与正常对照组比较,MD组大鼠超氧化物歧化酶、谷胱甘肽过氧化物酶活力显著降低,氧化应激增强;与MD组比较,姜黄素固体分散体组SOD、GSH-Px活力显著提高,MDA含量显著降低。结论姜黄素固体分散体可显著提高糖尿病大鼠的抗氧化能力,抑制氧化应激。OBJECTIVE To study the effects of curcumin solid dispersion on the oxidative stress in diabetic rats.METHODS The curcumin solid dispersion was prepared with excipient of polyvinylpyrrolidone.Diabetic rats that were induced by intraperitoneal injection of streptozotacin were randomly divided into five groups：diabetes mellitus（MD） group,polyvinylpyrrolidone（PVP） group,curcumin（CU） group,low dosage of curcumin solid dispersion（LSD） group,high dosage of curcumin solid dispersion（HSD） group.Six weeks after initiating treatment,the superoxide dismutase（SOD）,glutathione peroxidase（GSH-Px） and malondialdehtyde（MDA） were examined.RESULTS The diabetic rats compared with control group,the index of kidney increased significantly,the antioxidant capability of kidney decreased significantly;the rats that fed with curcumin solid dispersion compared with diabetic rats,the activity of superoxide dismutase and glutathione peroxidase increased significantly,the content of malondialchehyche decreased significantly.CONCLUSION The curcumin solid dispersion can increase the antioxidant capability of diabetic rats and decrease the oxidantive stress.

关 键 词：糖尿病模型 氧化应激 姜黄素 固体分散体 超氧化物歧化酶 谷胱甘肽过氧化物酶 

分 类 号：R965.2[医药卫生—药理学]