经轻胶囊对高雌大鼠神经递质影响的实验研究  

Impact of Jingqing Capsule on Contents of NT in Rats with high-level Estrogens

作　　者：胡心伟[1] 傅金英[2] 肖新春[3] 张庆文[1] 

机构地区：[1]成都中医药大学临床医学院,四川省成都市十二桥路37号610075 [2]河南中医学院 [3]陕西中医学院

出　　处：《世界中医药》2010年第1期64-66,共3页World Chinese Medicine

摘　　要：目的:考察外源性雌激素对大鼠神经递质变化的影响,探讨中药经轻胶囊的干预机制。方法:以皮下注射苯甲酸雌二醇造成大鼠体内高雌激素状态,设立空白对照组、雌激素模型组、雌激素+左洛复组、雌激素+经轻胶囊组,通过对实验大鼠的中枢神经递质5-HT、5-H IAA、NE、DA指标的考察,探讨经轻胶囊对高雌激素诱发的大鼠抑郁状态的可能干预机制。结果:外源性雌激素可造成大鼠中枢神经递质5-HT、5-H IAA、NE、DA的含量显著降低。结论:中药经轻胶囊可升高中枢神经递质的含量,纠正/控制这一状态。Objective： To explore the impact of exogenous estrogens on the neurotransmitters （NT） of rats in order to discover the intervention mechanism of Jingqing Capsule. Methods： The rats were injected subcutaneously with benzestrofol to achieve high-level estrogen. The treatment group was given Jiangqiao Capsules decoction and controlled by a normal group, a model group, and a group treated with Zoloft. Through determining the contents of 5-HT,5-HIAA ,NE ,DA, discussed was a possible intervention mechanism for depression induced by high-level estrogen. Results： Exogenous estrogen can significantly lower the levels of 5-HT ,5-HIAA, NE, DA in rats. Conclusion： Jingqing Capsule can treat or control depression induced by high-level estrogen through raising NT contents.

关 键 词：@经轻胶囊 雌二醇 神经递质 

分 类 号：R277.791.6[医药卫生—中医学] R961