瘦素与慢性肾功能衰竭  

Leptin and chronic renal failure

作　　者：姚小美[1] 刘子栋[1] 

机构地区：[1]山东大学医学院附属济南市中心医院血液净化科,济南250013

出　　处：《中国实用内科杂志》2010年第2期157-159,共3页Chinese Journal of Practical Internal Medicine

摘　　要：肾脏是瘦素的主要清除器官,同时瘦素又可对肾脏功能产生直接作用,影响慢性肾功能衰竭患者的疾病进程。高瘦素血症与尿毒症患者的厌食、营养不良及心血管疾病密切相关。不同透析方法对瘦素的清除作用不同。肾移植患者高瘦素血症可能影响其长期建立起来的免疫平衡状态。Leptin, a polypeptide hormone coded by Ob-gene, has the functions of depressing appetite, reducing caloric intake and enhancing caloric consumption, etc. Leptin has a close relationship with kidney, for it is metabolized and eliminated via kidney. Meanwhile, leptin can also directly affect kidney functions, influencing the process of chronic renal failure. Furthermore, hyper-leptinemia is associated with anorexia, malnutrition and cardiovascular diseases. Different dialysis patterns may also play different roles in cleaning leptin. For example, common dialysis could not clear leptin, but other dialysis modes such as high permeability dialysis, hemodiafiltration, and mastic absorption hemoperfusion can alleviate hyper-leptinemia through cleaning leptin partly. For kidney transplantation patients, hyper-leptinemia may affect the immune balance which has been maintained for a long time.

关 键 词：瘦素 肾脏 慢性肾功能衰竭 

分 类 号：R5[医药卫生—内科学]