紫外分光光度法测定硫酸链霉素鱼肝油滴鼻剂中主药的含量  

Determination of Principle Agents in Streptomycin Sulfate/Cod Liver Oil Nasal Drop by UV Spectrophotometry

作　　者：王承建[1] 何勇[1] 

机构地区：[1]遵义医学院附属医院药剂科,遵义市563000

出　　处：《中国药房》2010年第5期452-453,共2页China Pharmacy

摘　　要：目的:建立测定硫酸链霉素鱼肝油滴鼻剂中主药含量的方法。方法:采用紫外分光光度法,在检测波长为521nm条件下检测该制剂中硫酸链霉素的吸光度并计算含量。结果:硫酸链霉素检测浓度的线性范围为250～700μg·mL-(1r=0.9998);平均回收率为99.75%,RSD=0.98%。结论:本方法简便、准确,可用于该制剂的质量控制。OBJECTIVE： To establish a method for determination of the principle components in streptomycin sulfate in Streptomycin sulfate/cod liver oil nasal drop. METHODS： UV spectrophotometry was use to determine the absorption of streptomycin sulfate at detection wavelength of 521 nm. The content of streptomycin sulfate was also calculated. RESULTS： The detection concentration of streptomycin sulfate has favorable linear correlation within 250-700 μg·mL^-1 （r=0.999 8）. The average recovery was 99.75 % （RSD=0.98 % ）. CONCLUSION： The method is convenient, accurate and suitable for quality control of the preparation.

关 键 词：紫外分光光度法 硫酸链霉素鱼肝油滴鼻剂 含量测定 

分 类 号：R927.2[医药卫生—药学] R987