大豆苷元-水溶性壳聚糖固体分散体的制备  

Preparation of water-soluble chitosan solid dispersion of daidzein

作　　者：葛月宾[1] 王旭彬[1] 郭伟林[1] 谢晓敏[1] 

机构地区：[1]中南民族大学药学院,湖北武汉430074

出　　处：《中国中药杂志》2010年第3期293-296,共4页China Journal of Chinese Materia Medica

基　　金：中南民族大学自然科学基金项目(YZZ06030)

摘　　要：目的:制备大豆苷元-水溶性壳聚糖固体分散体。方法:溶剂法制备不同比例的大豆苷元-水溶性壳聚糖固体分散体,进行体外溶出试验,差示扫描量热法、X-射线粉末衍射法、红外光谱法物相鉴别固体分散体的形成。结果:制备的1∶5和1∶9比例固体分散体中,60min时药物的累积溶出百分率高达90%以上,而对应的物理混合物累积溶出仅约40%,原药溶出仅34.8%。物相鉴定表明,大豆苷元一部分形成低共熔物,以微晶状态分散在固体分散体中。结论:以水溶性壳聚糖为载体制备的固体分散体,有效地提高了难溶性药物大豆苷元的溶出速率。Objective： To enhance the dissolution rate of daidzein with solid dispersion technique. Method： Solid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic cartier. DSC, IR and X-ray methods were used to verify the formation of solid dispersion. Result： Dissolution percentages of solid dispersions were more than 90 percent in the drug-cartier ratio of 1 ： 5 and 1 ： 9. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline. Conclusion： Water-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.

关 键 词：大豆苷元 水溶性壳聚糖 固体分散体 溶出速率 

分 类 号：R283[医药卫生—中药学]