厚壳树叶化学成分研究  

Chemical contituents in leaves of Ehretia thyrsiflora

作　　者：李丽[1,2,3] 石任兵[2] 乌兰塔娜[1] 许利嘉[1] 彭勇[1] 肖培根[1] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所中草药物质基础与资源利用教育部重点实验室,北京100193 [2]北京中医药大学中药学院,北京100102 [3]广西药用植物园,广西南宁530023

出　　处：《中国中药杂志》2010年第3期331-332,共2页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金重点项目(30530860)

摘　　要：目的:对厚壳树Ehretia thyrsiflora干燥叶粗提物的各个部位进行化学成分研究。方法:利用硅胶柱色谱,Sepha-dex-LH20,反相C18柱色谱等手段进行分离纯化,根据理化性质和波谱数据进行结构鉴定。结果:从二氯甲烷及正丁醇部位分离了得到6个化合物,分别为β-谷甾醇(β-sitosterol,1),咖啡酸乙酯(ethyl caffeate,2),2-甲氧基苯甲酸辛酯(2-methoxylben-zoic acid octylester,3),十四烯酸甘油酯(tetradecenoic acid,2,3-dihydroxypropyl ester,4),胡萝卜苷(daucoster,5),尿囊素(al-lantoin,6)。结论:化合物1～5为首次从该种植物中分离得到,化合物2～5为首次从该属植物中分离得到。Objective： To investigate the chemical constituents of Ehretia thyrsiflora. Method： Compounds were isolated with silica gel, Sephadex LH-20 and RP-C18 colum chromatography. Their structures were elucidated by means of physico-chemical properties and spectral analysis. Result： Six compounds were isolated and identified as β-sitosterol （1）, ethyl caffeate （2）, 2-methoxyl benzoic acid octyl ester （ 3 ）, tetradecenoic acid, 2,3-dihydroxypropyl ester （ 4 ）, daucoster （ 5 ）, allantoin （ 6 ）. Conclusion ： Compounds 1-5 were obtained from this st3ecies for the first time. Compounds 2-5 were obtained from the genus Ehretia for the first time.

关 键 词：紫草科 厚壳树 化学成分 

分 类 号：R284[医药卫生—中药学]