肝细胞生长因子基因C57488A多态性及其血清水平和高血压的相关性研究  

Relationships of hypertension and polymorphism of hepatocyte growth factor gene C57488A and its serum level

作　　者：胡泽平[1] 王邦宁[1] 孟影[2] 

机构地区：[1]安徽医科大学第一附属医院心内科,合肥市230022 [2]安徽省合肥市第一人民医院心内科,230022

出　　处：《实用医学杂志》2010年第2期225-227,共3页The Journal of Practical Medicine

基　　金：安徽省科技攻关计划项目(编号:06013129B);安徽医科大学第一附属医院科研基金项目资助

摘　　要：目的:探讨中国合肥地区汉族人群中肝细胞生长因子(HGF)基因C57488A多态性及其血清水平与高血压的关系,并初步观察其多态性对血清HGF水平的影响。方法:对107例高血压患者及110例健康对照人群进行HGF基因C57488A多态性及其血清水平检测,采用SASP-PCR法检测基因多态性,采用双抗体夹心ELISA法检测血清HGF水平。结果:高血压组CC基因型、C等位基因频率和血清HGF水平均显著高于对照组(均P<0.01)。高血压组CC基因型者血清HGF水平较CA+AA基因型者相比有升高趋势(P=0.072)。结论:中国合肥地区汉族人群高血压的发生与HGF基因C57488A多态性有关,携带CC基因型和C等位基因可能是高血压的易感因素。高血压患者血清HGF水平显著升高,CC基因型的高血压患者血清HGF水平较CA﹢AA基因型者相比有升高趋势。Objective To explore the relationships of hypertension and polymorphism of hepatoeyte growth factor （HGF） gene C57488A and its serum level in Chinese Han nationality population in Hefei. Methods Polymorphism of HGF gene C57488A and its serum level were measured by SASP-PCR or sandwich ELISA in 107 patients with hypertension （hypertension group） and 110 healthy controls （control group）. Results The frequencies of genotype CC and allele C and serum level of HGF were significantly higher in hypertension group than those in control group （P 〈 0.01）. There was an increase trend of serum level of HGF in genotype CC as compared with those in genotype CA and AA in hypertension group （P = 0.072）. Conclusion HGF C57488A gene polymorphism is possibly associated with hypertension, and genotype CC and allele C may be the risk factors for hypertension in Chinese Han nationality population in Hefei.

关 键 词：肝细胞生长因子 基因多态性 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]