组织热凝固程度无损监控的光学断层成像研究  

Research on the Non-Invasive Monitoring of Tissue Regional Thermal Coagulation Based on Optical Tomography

作　　者：李韪韬[1] 钱志余[1] 李婷[1] 

机构地区：[1]南京航空航天大学自动化学院,江苏南京210016

出　　处：《光学学报》2010年第1期169-174,共6页Acta Optica Sinica

基　　金：国家863计划(2008AA02Z438);国家自然科学基金(30671997);江苏省自然科学基金(BK2009371)资助课题

摘　　要：提出了利用光学断层成像技术对组织热凝固程度进行无损在位监控的方法。在重建算法上采用不需要计算雅可比(Jacobian)矩阵的非线性多参数优化方法,采用了基于N进制分部编码的遗传算法作为优化策略,可以有效提高成像速度,克服计算雅克比矩阵带来的误差。采用简化的感兴趣区热疗模型,该模型最大程度的减小了对精度的影响。通过蛋白质凝固的实时监控实验,对监控方法进行了验证,给出了相应的监测结果,并从曲线、重建图像的临床意义等方面进行了分析。结果证明论文实现了通过约化散射系数对生物组织局部热凝固治疗过程无损实时监测的目的。A non-invasive in vivo monitoring method of tissue thermal coagulation based on optical tomography was proposed.The nonlinear multi-parameter optimization algorithm in the new reconstruction method was proposed,which was not based on the calculation of Jacobian matrix.N-decimal system parted coding operator genetic algorithm was used as optimization algorithm.The new reconstruction method could improve the reconstruction speed,avoid the ill-conditioned problem and calculation error of Jacobian matrix.A simplified region of interest model of thermal coagulation was given,which came at the least price of reduced precision.The monitoring method was proved by the experiment of egg white.The curves,reconstruction images and clinic significance were studied.It can be concluded that the reduced scattering coefficient image,got by optical tomography,can be used to evaluate the process of thermal coagulation non-invasively.

关 键 词：组织光学 热凝固监控 光学断层成像 遗传算法 近红外 

分 类 号：O436[机械工程—光学工程] R445[理学—光学]