沉香化滞丸质量标准研究  

Quality Standards of Chenxiang Huazhi Pills

作　　者：郭巧技[1] 肖丽和[1] 熊英[1] 

机构地区：[1]深圳市药品检验所,深圳市518029

出　　处：《中国药房》2010年第7期632-634,共3页China Pharmacy

摘　　要：目的:建立沉香化滞丸的质量标准。方法:采用薄层色谱(TLC)法对制剂中的木香、香附、山楂、大黄、厚朴、牵牛子进行定性鉴别;采用高效液相色谱法测定制剂中橙皮苷的含量。结果:TLC显色清晰且阴性对照无干扰。橙皮苷的检测浓度在0.0242～0.4832mg·mL-1范围内与峰面积积分值呈良好的线性关系(r=0.9994);平均回收率为102.5%,RSD=2.0%(n=6)。结论:所建标准可用于沉香化滞丸的质量控制。OBJECTIVE：To develop a method for quality control of Chenxiang huazhi pills. METHODS ：Auklandia lappa, Cyperus rotundus, Crataegus pinnati fida, Rheum palmatum, Magnoliae officinalis and Pharbitis nil were identified by TLC. HPLC was used for determination of hesperidin. RESULTS： The chromatographic spots were identified without interference of negative con- trol. Hesperidin had a good linearity within the range of 0.024 240.483 2 mg-mL ;（r=0.999 4）with average recovery of 102.5% （RSD=2.0% ,n=6）. CONCLUSION： This standard is used for quality control of Chenxiang huazhi pills.

关 键 词：薄层色谱法 高效液相色谱法 沉香化滞丸 质量标准 橙皮苷 

分 类 号：R283.64[医药卫生—中药学] R927.1[医药卫生—中医学]