姜黄素微囊在大鼠体内的药代动力学研究  

Pharmacokinetics of Curcumin Microcystin in Rats

作　　者：曾晓会[1] 陈玉兴[1] 赵自明[1] 黄雪君[1] 杜铁良[1] 

机构地区：[1]广东省中医研究所,广东广州510095

出　　处：《中国实验方剂学杂志》2010年第2期107-110,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省科技厅火炬计划项目(2005A30101016)

摘　　要：目的:研究姜黄素微囊在大鼠体内的药代动力学过程。方法:采用口服给药,进行颈动脉插管,分别于药后0.08,0.25,0.5,0.75,1,2,3,4,5.5 h采血,用HPLC进行检测。结果:姜黄素微囊各剂量的药时曲线呈双峰现象;各剂量组的Cm ax1和Cm ax2分别为:高剂量(0.90 mg/L和1.20 mg/L)、中剂量(0.43 mg/L和0.46 mg/L)、低剂量(3.16 mg/L和1.31 mg/L);姜黄素微囊高、中、低3个剂量AUC分别为3.79,2.60,5.92 mg.h/L,低剂量比高中剂量的Cm ax和AUC都大。结论:姜黄素微囊在大鼠体内的药代动力学呈非线性过程,可能存在肠肝循环现象。Objective：To study the pharmacokinetics of curcumin microcystin in rats.Methods： The microcystin was orally administrated.After carotid artery cannulation,blood samples were collected after administration of 0.08,0.25,0.5,0.75,1,2,3,4,5.5 h,and tested by HPLC.Results： The various doses of curcumin concentration-time curve is bimodal;Cmax_1 and Cmax_2 of each dose group are as follows： high-dose（0.90,1.20 mg/L）,medium dose（0.43,0.46 mg/L）,low dose（3.16,1.31 mg/L）; AUC are 3.79,2.60,5.92 mg·h/L respectively.Cmax and AUC of low dose are greater than that of the high and medium doses.Conclusion： The Pharmacokinetics of curcumin were nonlinear process in rat,there may be the phenomenon of enterohepatic circulation.

关 键 词：姜黄素微囊 药代动力学 大鼠 

分 类 号：R285.5[医药卫生—中药学]