HLA-G蛋白在不同孕期胎盘绒毛中的表达及意义  

Expression of HLA-G in Chorionic Villi at Different Stages of Gestation

作　　者：朱晓明[1] 尹国武[1] 王晓红[1] 杨华光[1] 罗亚宁[1] 

机构地区：[1]第四军医大学唐都医院妇产科,西安710038

出　　处：《科学技术与工程》2010年第3期760-761,765,共3页Science Technology and Engineering

摘　　要：人类白细胞抗原-G(HLA-G)主要表达于胎盘组织中,在维持母胎界面的免疫耐受过程中发挥着关键作用。为研究HLA-G在正常胎盘形成过程中的表达模式,实验检测了妊娠不同阶段的胎盘绒毛组织中HLA-G蛋白的表达水平。实验结果显示HLA-G蛋白在孕6周与7周的绒毛中表达量最高,从孕8周开始,表达量逐渐下降,至足月时,表达量达到最低水平。由此推测HLA-G在妊娠早、中期与胎盘形成有关,在妊娠晚期可能参与妊娠维持。Human leukocyte antigen-G （HLA-G） is expressed in placenta, in which it thought to play a key role in maintaining the maternal-fetal immune tolerance. The expression of HLA-G in human chorionic villi is examined at different stages of gestation to investigate the expression pattern of HLA-G during normal placentation. The results showed that HLA-G protein expression reached a peak level at gestational weeks 6 and 7, then gradually decreased from week 8 to third trimester in normal chorionic villi. These results lead us to propose that HLA-G may contribute to placentation during early and mid-term pregnancy, and participate in maintaining gestation during term pregnancy.

关 键 词：人类白细胞抗原-G 绒毛 妊娠 

分 类 号：R714.12[医药卫生—妇产科学]