加味四逆散对肠易激综合征大鼠不同脑区核团c-fos蛋白表达的影响  

Effects of JiaWei Sini Power on Expression of c-fos in Different Brain Areas and Nucleus of Rats with Irritable Bowel Syndrome

作　　者：白霞[1] 谢小磊[1] 李梦[1] 耿建国[1] 李冬华[1] 杜宇琼[1] 

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《中国中医基础医学杂志》2010年第1期40-41,共2页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家中医药管理局中医药科学技术研究专项资助项目(06-07ZQ01)

摘　　要：目的:观察加味四逆散对肠易激综合征大鼠不同脑区核团c-fos蛋白表达的影响。方法:采用束缚制动加灌服番泻叶改良的方法制备肠易激综合征大鼠模型,将24只W istar大鼠随机分成正常组、模型对照组、加味四逆散组和得舒特组,用免疫组织化学法检测大鼠大脑皮质和纹状体c-fos阳性神经元的变化。结果:加味四逆散可明显降低大鼠脑皮质和纹状体c-fos阳性神经元的数目。结论:加味四逆散能够降低c-fos在IBS大鼠不同脑区核团的蛋白表达,干预脑肠轴紊乱的调控机制。Objective：To observe the effect of Jiawei Sini Dection on expression of c-fos protein in different brain areas in rats of irritable bowel syndrome （IBS）. Method：The rat model of irritable bowel syndrome was made by binding stress with taking senna decoction,Twenty -four Wistar rats were divided randomly into normal group, model group, Jaiwei sinisan group and Dicetel group. The change in the number of c-los positive neurons were detected by immunohistochemistry in rat cortex and striatum. Results ： Jiawei Sini Decoction could significantly reduce the number of c-los positive neurons in rat cortex and striatum. Conclusion ：Jiawei Sini Decoction could reduce the expression of c-los in different nucleis of brain regions of IBS rats to investigate the regulatory mechanism of brain-gut interaction.

关 键 词：加味四逆散 肠易激综合征 C-FOS蛋白表达 

分 类 号：R285.5[医药卫生—中药学]