青霉素过敏反应与IL-4Rα Q576R及FcεRIβ E237G基因多态性  

IL-4Rα Q576R and FcεRIβ E237G gene polymorphisms: association with allergic reaction to penicillin

作　　者：张跃文[1] 乔海灵[1] 

机构地区：[1]郑州大学临床药理研究所,郑州450052

出　　处：《中国抗生素杂志》2010年第1期65-68,共4页Chinese Journal of Antibiotics

基　　金：河南省杰出青年基金资助项目(0312002100);河南省自然科学基金资助项目(0211040100);河南省医学创新人才工程项(2002114)

摘　　要：目的探讨青霉素类抗生素过敏反应与IL-4RαQ576R及FcεRIβE237G基因多态性的关系。方法采用ELISA检测了51例过敏患者血清中的IL-4、INF-γ浓度;采用PCR-RFLP检测了51例过敏患者和53例正常对照的IL-4RαQ576R及FcεRIβE237G多态性位点的基因型。结果IL-4RαQ576R位点QQ(AA)基因型患者所占比例在过敏患者中显著高于正常组(P<0.05);位点含G等位基因患者血清中pvo,bpa浓度显著高于EE基因型患者(P<0.05)。结论IL-4RαQ576R位点可能与青霉素过敏反应有关;FcεRIβE237G多态性可能与某些青霉素特异性IgE抗体升高有关。Objective To determine the correlation between allergic reaction to penicillin and IL- 4RαQ576R,FcεRIβ E237G gene polymorphisms. Methods IL-4, INF-7 in serum among 51 patients with allergic reaction to penicillin were examined by enzyme linked immunosorbent assay （ELISA）, and the candidate loci genic polymorphisms IL-4Rα Q576R and FcεRIβ E237G of 51 allergic patients and 53 control subjects by PCR-RFLP. Results IL-4Rα Q576R-AA allele was found more frequently in allergic patients than normal controls （P〈0.05）. Patients with G Allele in FcεRIβ E237G polymorphism had significantly higher pro and bpa antibodies levels than patients with EE Genotype （P〈0.05） . Conclusions The result showed that the IL-4Rα Q576R-AA allele was statistically associated with penicillin allergy, the distributions of FcεRIβE237G genotype may have a correlation to penicillin specific IgE antibodies.

关 键 词：青霉素 过敏 基因多态性 

分 类 号：R978.11[医药卫生—药品]