9-芴甲氧羰基-对甲磺酰氨-(L)-苯丙氨酸的全合成  

Total Synthesis and characterization of 9-Fmoc-sulfonylurea acyl ammonia-L-Phenylalanine

作　　者：马燕[1] 王朝阳 

机构地区：[1]西南科技大学生命科学与工程学院,四川绵阳620010 [2]四川成都爱斯特医药技术有限公司,四川成都611130

出　　处：《化工中间体》2010年第1期35-38,27,共4页

摘　　要：(L)-苯丙氨酸经硝化、酯化、叔丁氧羰基(Boc)保护α氨基、Pd/C还原对位硝基、对甲磺酰氯(MSCl)保护对位氨基、经水解反应后,在酸性条件下脱去叔丁氧羰基(Boc)基团,碱性条件下引入9-芴甲氧羰基琥珀酰亚胺(Fmoc-osu),最终生成标题化合物,并且所合成标题化合物进行了HNMR结构确证。The title compound was synthesized from L-phenylalamine via nitration,esterification,the amino of L-phenylalamine was protected using base-liable Boc group,the reduction of para-nitryl was completed by Pd/C,the paraamino group was protected using methylsufonyl chloride,after via saponification,Boc was removed in acid condition ,and Fmoc-osu could introduce Fmoc group in basic condition,finally the target compound was obtained,the structure was confirmed by 1HNMR spectra.

关 键 词：(L)-苯丙氨酸 芴甲氧羰酰琥珀酰亚胺(Fmoc-osu) 对甲磺酰氯(MSCl) 合成 保护 

分 类 号：TQ264.37[化学工程—有机化工]