HAPC患者红细胞2,3-二磷酸甘油酸的变化和红细胞ATP酶的活性  

RELATIONSHIP BETWEEN ERYTHROCYTE 2,3—DIPHOSPHOGLYCRERATE AND ATPase IN PATIENTS WITH HIGH ALTITUDE POLYCYTHEMIA

作　　者：邹春华[1] 郑华金[1] 薛增军[2] 李素芝[2] 牟信兵[2] 

机构地区：[1]成都军区总医院血液科 [2]西藏军区总医院高山科

出　　处：《高原医学杂志》1998年第4期6-7,共2页Journal of High Altitude Medicine

摘　　要：目的：了解红细胞２，３－二磷酸甘油酸、红细胞膜ＡＴＰ酶在高原红细胞增多症（ＨＡＰＣ）的变化及二者关系。方法：ＨＡＰＣ患者２４例，正常对照１９例，分别测定红细胞２，３－二磷酸甘油酸，红细胞膜ＡＴＰ酶（Ｎａ＋－Ｋ＋－ＡＴＰ酶，Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性。结果：ＨＡＰＣ组及对照组红细胞２，３－二磷酸甘油分别为：３．２１ｍｍｏｌ／Ｌ±０．１３ｍｍｏｌ／Ｌ，４．８７ｍｍｏｌ／Ｌ±０．０７ｍｍｏｌ／Ｌ，（Ｐ＜０．０５）；Ｎａ＋－Ｋ＋－ＡＴＰ酶活性分别为：４．１±０．０１３λΒ／μｍｏｌ·ｈ－１·ｇ－１，７．４±０．１９λΒ／μｍｏｌ·ｈ－１·ｇ－１（Ｐ＜０．０１）；Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶活性分别为１５．１±１．７０λΒ／μｍｏｌ·ｈ－１·ｇ－１，２５．３±２．３１λΒμｍｏｌ·ｈ－１·ｇ－１（Ｐ＜０．０１）；相关分析显示：２，３－二磷酸甘油酸与Ｎａ＋－Ｋ＋－ＡＴＰ酶呈正相关（ｒ＋０．４８１７，Ｐ＜０．０１）与Ｃａ２＋－Ｍｇ２＋－ＡＴＰ酶呈正相关（ｒ＝０．４７８３，Ｐ＜０．０１）。结论：ＨＡＰＣ患者红细胞２，３－二磷酸甘油酸的减少，红细胞膜ＡＴＰ酶活力降低，反映机体缺氧状况。Objective:To understand the relationship between 2,3-diphosphoglycerate and erythrocyte membtane ATPase in patients with high altitude polycythemia(HAPC).Methods:Subjects included 24 cases with HAPC (mean aged 30 7 years,men 17,women 7)and 19 cases control(mean aged 28.9 years,men 13,womon 6) at high altitude (3 600～4 600m). Their erythrocyte 2,3-diphosphoglycerate, membrane ATPsas and Ca 2+ —Mg 2+ —ATPase were measured.Results:level of 2,3-diphosphoglycerate and ATPase decreased in HAPC group compared with control;and there was a positive correction between both the changes( r=0 4817,P <0 01 or r=0 4783,P <0 01).Conclusion:The lowed degree of level of 2,3-diphosphoglycerate and ATPase in HAPC suggests the situation of hpoxia and its metabolism in patients with HAPC.

关 键 词：高原 红细胞增多 红细胞 ATP酶 二磷酸甘油酸 

分 类 号：R555.102[医药卫生—血液循环系统疾病] R594.3[医药卫生—内科学]