肾上腺髓质素与肾上腺紧张素在维持性血透中的变化  

The Change of ADM_(13)～(52) and ADM_(153)～(185) in MHD

作　　者：张昭馥[1] 董葆[1] 张志勇[1] 石湘芸[2] 赵云涛[2] 田青[3] 张肇康[4] 唐朝枢[5] 

机构地区：[1]海军总医院肾内科 [2]海军总医院心内科 [3]PhoenixPharmaceuticals [4]Phoenix [5]北京医科大学心血管基础研究所

出　　处：《海军总医院学报》1998年第3期147-151,共5页Journal of Naval General Hospital of PLA

摘　　要：本文应用放免法测定了32例维持性血透患者透析前后血浆肾上腺髓质素(ADM_(13~32))及前体肾上腺紧张素(ADM_(153~185))水平,发现ADM较正常人明显增高,P<0.001,而ADM_(153~185)明显下降,P<0.01,前者与MAP、血浆BUN、ET有明显相关性,r值分别为0.492、0.743、0.492,而后者与MAP,BUN、ET无关.血液透析后ADM_(13~52)与ADM_(153~185)均无明显变化,它们的改变与BUN、Cr、HCO_(?)、K^+、Na^+、C1-、MAP、渗透压等变化无关.提示ADM、ADM_(153~185)这种新发现的血管活性物质参与了循环与血压的调节,它们的平衡失调可能是肾性高血压的原因之一.血液透析的急性效果对ADM_(13~52)、ADM_(153~185)无明显影响.We assayed the level of ADM13~52 and ADM153~185 in 32 patients by RIA. The re-sults showed that ADM13~52 was markedly higher than those of the normal human (P<0. 001),but ADM153~185 was markedly lower (P<0.01). There was a positive relationship betweenADM13~52 and MAP、blood plasma BUN、ET、but ADM153~185 was not. After dialysis bothADM13~52 and ADM153~185 did not change markedly. Their change had no relation with the changeof BUN、Cr、HCO3、K+、Na+、Cl-、MAP、Osm etc. The result showed that ADM13~52 andADM153~185,which is newly found vaso-active substance, adjust circuit and BP, their unadjustedmay be one of the reasons which lead to renal hypertension, the acute effect of HD does not effectADM13~52 and ADM153~185 definitly.

关 键 词：肾上腺髓质素 肾上腺紧张素 血管活性多肽 

分 类 号：R459.5[医药卫生—治疗学]