乙肝清热解毒胶囊联合拉米夫定治疗活动性肝炎肝硬化临床研究  

Clinical observation of combination of hepatitis B Qingrejiedu capsule and lamivudine on active cirrhosis

作　　者：徐菁[1] 黄桂芹[2] 耿建洪 

机构地区：[1]河北省沧州市传染病医院感染二科,河北沧州061001 [2]河北省沧州市传染病医院医务科,河北沧州061001 [3]河北省沧州市传染病医院感染一科,河北沧州061001

出　　处：《河北中医》2009年第10期1508-1510,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察乙型肝炎清热解毒胶囊联合拉米夫定治疗活动性肝炎肝硬化的临床疗效。方法将乙型肝炎病毒DNA(HBV-DNA)、乙型肝炎表面抗原(HBsAg)阳性,中医辨证为肝胆湿热型的活动型肝炎肝硬化患者173例随机分为2组。治疗组102例予乙型肝炎清热解毒胶囊,每次6粒,每日3次口服;同时予拉米夫定,每次100 mg,每日1次口服,疗程1年。对照组71例予拉米夫定,每次100 mg,每日1次口服,疗程1年。观察2组血清HBV-DNA、HBsAg、乙型肝炎e抗原(HBeAg)阴转率和肝功能变化。结果治疗组HBsAg阴转率为5.9%,对照组阴转率为7.0%,2组比较差异无统计学意义(P>0.05);治疗组HBV-DNA阴转率67.6%、HBeAg阴转率32.4%,对照组HBV-DNA阴转率42.3%、HBeAg阴转率12.2%,2组比较差异均有统计学意义(P<0.05);肝功能指标改善及Child-Pugh评分下降治疗组较对照组明显(P<0.01)。结论乙型肝炎清热解毒胶囊联合拉米夫定对肝胆湿热型的活动性肝炎肝硬化疗效理想,能有效抑制HBV复制。Objective To evaluate the clinical effect of combination of hepatitis B Qingrejiedu capsule and lamivudine on active cirrhosis. Methods 173 patients with active cirrhosis （positive of HBV - DNA, HbsAg） , which was the type of liver and gallbladder damp heat according to syndrome differentiation of traditional Chinese medicine, were randomly divided into two groups. Patients in the control group （ n =71 ） were treated by lamivudine, 100mg, once a day. The patients in the treatment group （ n = 102） were administrated with combination of hep- atitis B Qingrejiedu capsules （6 pills, thrice a day） and lamivudine. The therapeutic course was one year in two groups. The negative conversion rate of serum HBV - DNA, HBsAg and HBeAg and liver function changes were observed in two groups. Results The negative conversion rate of HBsAg in treatment group is 7.8% and the negative conversion rate of HBsAg in control group is 7%. There was no significant difference between twp groups （ P 〉 0.05）. The negative conversion rate of HBV - DNA, HBeAg in treatment group （67.6%, 32.4% ） were higher than those in the control group （42.3%, 12.2% , P 〈 0.05 ）. Compared with the comparison group, the liver function indicators improvement and Child - Pugh score decreased significantly in the treatment group （ P 〈0. 01 ）. Conclusion The combination of hepatitis B Qingrejiedu capsule and lamivudine has an ideal effect on the treatment of active cirrhosis, which was the type of liver and gallbladder damp heat according to syndrome differentiation of traditional Chinese medicine. It can effectively inhibit HBV duplication, no adverse reactions.

关 键 词：肝炎 慢性 并发症 肝硬化 中西医结合疗法 

分 类 号：R512.605.8[医药卫生—内科学] R977.3[医药卫生—临床医学]