单次静滴头孢吡肟在中国维吾尔族和汉族健康人体的药代动力学  

Pharmacokinetics of cefepime injection after a single dose in Chinese healthy Uigur and Han volunteers

作　　者：郭涛[1] 段威[1,2] 夏东亚[1] 曾平[3] 刘璟[3] 地里夏提.白克力 

机构地区：[1]沈阳军区总医院药剂科,沈阳110016 [2]沈阳药科大学,沈阳110016 [3]兰州军区乌鲁木齐总医院药剂科,乌鲁木齐830000

出　　处：《中国临床药理学杂志》2009年第6期495-497,共3页The Chinese Journal of Clinical Pharmacology

基　　金：全军医学科学技术研究“十一五”计划科技攻关课题基金资助项目(06G023)

摘　　要：目的研究维吾尔族健康志愿者单次静脉滴注盐酸头孢吡肟(第4代头孢菌素类抗生素)后的药代动力学,并与汉族进行比较。方法健康维吾尔族和汉族志愿者各10名,男女各半,单次静脉滴注盐酸头孢吡肟1.0g,定时采血,用RP-HPLC法测定头孢吡肟的血药浓度,用DAS2.0软件进行数据处理,用SPSS11.5软件进行统计分析。结果维吾尔族和汉族健康志愿者主要药代动力学参数:Cmax分别为(83.19±10.31)、(68.75±10.41)mg.L-1;t1/2β分别为(2.06±0.33)、(1.97±0.20)h;AUC(0-10.5)分别为(162.00±24.22)、(136.89±23.02)mg.h.L-1;AUC(0-∞)分别为(165.58±24.49)、(139.69±23.78)mg.h.L-1。结论维、汉2民族的种族差异对头孢吡肟的药代动力学无影响。Objective To investigate the pharmacokinetics of cefepime after a single intravenous administration in Chinese healthy Uigur and Hart volunteers. Methods Ten Chinese healthy Uigur and ten Han volunteers were involved in the study. Each subject received a single dose of 1.0 g cefepime hydrochloride. The plasma concentration was determined by RP - HPLC method. The pharmacokinetie parameters were calculated by DAS 2.0 software and were compared by SPSS11.5 software. Results The main pharmacokinetic parameters of 2 races were as follows： C were （ 83.19 ±10. 31） , （ 68. 75 ±10.41）mg· L^-1;t1/2βere（2.06 ± 0.33）, （1.97 ± 0.20） h;AUC（0-10.5） were （162.00 ± 24.22）, （136.89 ± 23.02） mg ·h· L^-1 ;AUC（0-∞） were （165.58±24.49）,（139.69 ±23.78）mg · h· L^-1. Conclusion The difference of ethnic between Chinese Uigur and Han had no influence on the pharrnacokinetics of eefepime.

关 键 词：头孢吡肟 反相高效液相色谱法 药代动力学 维吾尔族 汉族 

分 类 号：R691.1[医药卫生—泌尿科学] R978.11[医药卫生—外科学]