脂多糖相关受体及其介导的信号转导通路  

Receptors Associated to Lipopolysaccharide and Signal Pathway Mediated by the Receptors

作　　者：孙佳[1] 夏海鸣[1] 

机构地区：[1]东南大学附属第二医院传染科,南京210009

出　　处：《医学综述》2010年第3期324-327,共4页Medical Recapitulate

基　　金：南京市科技发展计划项目(200901093)

摘　　要：脂多糖(LPS)的识别与跨膜信号转导需要一系列分子的参与,如LPS结合蛋白、杀菌性/通透性增加蛋白、CD14、Toll样受体4等,是引起细胞炎性效应的关键,这一转导过程也是导致感染性休克、全身炎性反应综合征和多器官功能衰竭等疾病的重要机制。Toll样受体4与LPS结合后,活化髓样分化因子88依赖性和非依赖性两条信号途径。前者活化丝裂原激活的蛋白激酶和核因子κB信号通路,后者活化核因子κB和干扰素调节因子3信号通路。研究通路中的信号传递分子和信号转导环节可以为临床治疗寻找"新靶点"。A series of adaptor molecules are necessary in the recognition of lipopolysaccharide （LPS） and the transmembrane signal transduction, such as lipopolysaccharide binding protein, bactericidal permeability-increasing protein,CD14 ,TLR4 and so on. The processes are key events leading to inflammatory effects of the cells and significant mechanism involved in many disorders such as septic shock, systemic inflammatory response syndrome and multiple organ dysfunction syndrome. When bound by LPS, TLR4 activates 2 signaling pathways： a myeloid differentiation factor 88 （MyD88）dependent pathway activates mitogen-activated protein kinase （MAPK）and NF-κB, and a MyD88 independent pathway activates NF-κB and IFN-regulated factor-3. Studies of the molecules and links involved in the signal transduction will help to find new targets in clinical therapy.

关 键 词：脂多糖 CD14 TOLL样受体4 信号转导 MYD88 

分 类 号：R392.11[医药卫生—免疫学]