毛细管气相色谱法建立中药莪术油指纹图谱研究  

Fingerprint of Zedoary turmeric oil by GC

作　　者：李想[1] 孙艳涛[1] 张振秋[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《中成药》2010年第2期176-179,共4页Chinese Traditional Patent Medicine

摘　　要：目的:建立莪术油的指纹图谱测定分析方法,为莪术油的质量控制提供参考。方法:采用GC法对12批莪术油进行指纹图谱测定,采用Excel计算指纹图谱的相似度,并采用SPSS进行聚类分析。结果:17批莪术油的相似度计算结果较低;通过聚类分析结果可将莪术油分为两类,自制莪术油和市售莪术油各为一类,但辽宁和江苏产药材提取的莪术油差异较大,无法成为一类。因此基于聚类分析结果,分别建立了自制莪术油和市售莪术油的指纹图谱的共有模式,并具有较高的相似度。结论:自制莪术油和市售莪术油无法建立共有指纹图谱,应进一步对市售莪术油的质量标准进行研究,从而控制莪术油及其中药制剂的质量。AIM： To establish the method of fingerprinting analysis on Zedoary turmeric oil by GC. Zedoary turmeric oil for the quality control of reference. METHODS ： GC method was used to determine the fingerprint and its similarity of Zedoary turmeric oil calculated on Excel and cluster analysis. RESULTS： Seventeen samples of Zedoary turmeric oil indicated that there was a little similarity among them. Based on the cluster analysis, all the Zedoary turmeric oils could be divided into two categories, self-made and market purchasing oil, the latter oils purchased from Liaoning province and Jiangsu province varied considerably. Every category had a common fingerprint mode with clear resemblance. CONCLUSION： When finding the difference between the self-made and the marketpurchasing Zedoary turmeric oil, quality control requires serious consideration.

关 键 词：莪术油 GC指纹图谱 相似度 聚类分析 

分 类 号：R284.1[医药卫生—中药学]