雷公藤内酯醇复方乳膏剂皮肤毒理及其透皮吸收性能研究  

Dermal toxicology and absorption of Triptolide Compound Cream

作　　者：龙正海[1] 韦登明[2] 杜纪斌 

机构地区：[1]浙江医药高等专科学校,浙江宁波315100 [2]宁波大学医学院,浙江宁波315211 [3]浙江全盛药业有限公司,浙江慈溪315301

出　　处：《中成药》2010年第2期213-218,共6页Chinese Traditional Patent Medicine

基　　金：宁波市社会发展攻关项目[2006C100059]

摘　　要：目的:研究雷公藤内酯醇复方乳膏剂的皮肤毒理和透皮吸收性能。方法:以2%氮酮和1%油茶树嫩枝挥发油作为促进剂,制备雷公藤内酯醇复方乳膏剂。并通过活体大鼠皮肤毒理实验和离体大鼠皮肤渗透释药实验,评价其皮肤毒性及透皮吸收效果。结果:实验结果说明该乳膏剂无皮肤刺激性、致敏性和急性毒性,2%氮酮+1%油茶树嫩枝挥发油对乳膏剂中雷公藤内酯醇和美洛昔康这两种成分的促透作用明显,在透皮12 h后,这两种成分的单位面积透皮释药量(Q/(μg/cm2))和透皮吸收百分率(Q%)均达到稳态值,结果还表明Q/(μg/cm2)与渗透时间有较好的线性关系。结论:研究表明该乳膏剂无明显的皮肤毒性,其透皮吸收性能良好。AIM： To study the dermal toxicity and absorption of Triptolide Compound Cream. METHODS： 2% azone ＋ 1% volatile oil of twig from Camellia. oleifera was used as permeation enhancer to prepare Triptolide Compound Cream. Acute dermal toxicity, irritation a sensitization test on mouse were carried out. And mouse skin in vitro was applied for studying the administration. RESULTS： This compound cream had no acute toxicity, irritation or hypersensitive effects. 2% azone ＋ 1% volatile oil had more powerful enhancement effects, after 12 h, amont of drug delivery/unit area Q/（ μg/cm2 ） and absorption percentage Q% of triptolide and meloxiean in the preparation reached a platea conventration. The results also showed that there was a good linear correlation between the accumulative permeated amount per unit area and the time. CONCLUSION： The study showed that Triptolide Compound Cream has no toxicity on skin, and there is a good dermal absorption.

关 键 词：雷公藤内酯醇 复方乳膏剂 皮肤毒理 透皮吸收性能 

分 类 号：R944[医药卫生—药剂学]