氨布洛芬合成工艺的优化  

Optimization on Synthetic Technology of Aminoprofen

作　　者：钟光祥[1] 蒋剑松[1] 陈路路[1] 

机构地区：[1]浙江工业大学药学院,浙江杭州310032

出　　处：《合成化学》2010年第1期137-139,共3页Chinese Journal of Synthetic Chemistry

摘　　要：对氨布洛芬的合成工艺进行了优化。以甲苯为溶剂,布洛芬经酰氯化制得布洛芬酰氯;K2CO3作缚酸剂,布洛芬酰氯与乙醇胺完成酰胺化反应合成了氨布洛芬,收率94.4%,纯度99.09%。Synthtic technology of Aminoprofen was optimized. Aminoprofen in yield of 94.4% with the purity of 99.09% was synthesized by a two-step reaction of acyl chlorination from Ibuprofen and SOCl2 in toluene, and amidation from Ibuprofen chloride and ethanolamine using K2CO3 as the acid binding agent.

关 键 词：氨布洛芬 布洛芬 工艺优化 药物合成 

分 类 号：O623.731[理学—有机化学] R914.5[理学—化学]