化学药物联合免疫调节剂治疗煤工尘肺结核疗效观察  

Observation on Effect of Chemotherapy Combined With Immunomodulator on Pneumoconio-tuberculosis

作　　者：高劲松[1] 

机构地区：[1]淮北矿业集团职业病防治院,安徽淮北235000

出　　处：《职业卫生与病伤》2010年第1期13-15,共3页Occupational Health and Damage

摘　　要：目的观察化学药物联合免疫调节剂治疗煤工尘肺结核的疗效。方法随机将81例煤工尘肺结核患者分为治疗组及对照组,两组化疗方案相同,治疗组加用免疫调节剂,观察治疗前后痰菌阴转率、病变吸收好转率、空洞闭合率及临床症状的改善,分析其疗效。结果治疗结束后治疗组和对照组痰菌阴转率分别为92.8%、69.2%,X线影象结果表明两组的病灶显效率分别为76.5%、47.5%,肺部病变吸收总有效率95.1%、67.5%,空洞闭合率82.2%、59.3%,两组比较差异有统计学意义(P<0.05)。临床症状咳嗽、咳痰、胸痛、呼吸困难、乏力等症状有改善,治疗组改善程度均大于对照组。结论化学药物联合免疫调节剂治疗煤工尘肺结核疗效较好。其机制可能是通过增强机体细胞免疫功能而实现。Objective To evaluate the effect of routine chemotherapy combined with immunomodulator on pneumoconio-tuberculosis. Methods Eighty one patients with pneumoconio-tuberculosis were randomly divided into trial group and control group. All the patients were treated with the same chemotherapy, but the treatment in trial group were combined with immunomodulator, the effects were compared at the end of the treatment. Results At the end of the treatment, the sputum negative conversion rate was 92. 8% in trial group, and 69.2% in control group, the improving rates according to chest X-ray check in trial group and control group were 76.5% and 47.5% respectively, the effective rates were 95.1% and 67.5% and the cavi- ty closure rates were 82. 8% and 59.3% with statistically significant difference （P 〈0. 05）. The symptom of cough, expectoration, ehestpain, hypodynamia were mitigated greatly in trial group than in control group. Conclusion Chemotherapy combined with immunornodulator is more effective in treating pneumoconio-tuberculosis by the possible mechanism of improving cellular immunity.

关 键 词：尘肺结核 免疫调节剂 转移因子 螺旋藻 

分 类 号：R135.2[医药卫生—劳动卫生]