白介素-4和白介素-8在高原地区慢性肺心病发病机制中的作用和临床意义  

Function and clinical significance of IL-4 and IL-8 in the patients with high altitude chronic cor pulmonale

作　　者：杨生岳[1] 沈君礼[1] 冯恩志[1] 郭振援[1] 黄宁侠[1] 张瑛[1] 陈宗茹[1] 种银侠[1] 张花[1] 

机构地区：[1]解放军第四医院呼吸内科,青海西宁810007

出　　处：《西北国防医学杂志》2010年第1期34-36,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的:探讨白介素-4(IL-4)和白介素-8(IL-8)在高原慢性肺心病发病机制中的作用和意义。方法:高原肺心病急性加重期患者66例、缓解期患者61例,健康对照组35例,分别测血清IL-4、IL-8、肺功能和血气。结果:肺心病急性加重期血清IL-4、IL-8、PaCO2高于缓解期,缓解期高于对照组(P均<0.01),急性加重期FEV1%、FEV1/FVC、PaO2低于缓解期,缓解期低于对照组(P均<0.01)。急性加重期和缓解期血清IL-4、IL-8与FEV1%、FEV1/FVC、PaO2呈负相关,与PaCO2呈正相关(P均<0.01)。结论:IL-4、IL-8参与了高原肺心病的气道炎症反应。检测血清IL-4、IL-8浓度变化可作为高原肺心病患者病情和疗效判断的有效指标。Objective：To investigate the function and clinical significance of IL-4 and IL-8 in the patients with high altitude chronic cor pulmonale（HACCP）.Methods： Sixty-six patients at acute stage of HACCP and 61 patients at remission stage were included.Thirty-five healthy volunteers were used as controls.Their serous level of IL-4,IL-8,lung function and PaCO2 were measured.Results：The patients at acute stage had significantly higher serous IL-4 and IL-8 level and PaCO2 than the patients at remission stage（P0.01）.The patients at remission stage had significantly higher indexes than those of the controls（P0.01）.The serous concentrations of IL-4 and IL-8 in the patients at acute and remission stage were negatively correlated with FEV1%,FEV1/FVC,and PaO2,but was positively correlated with PaCO2（P0.01）.Conclusion：IL-4 and IL-8 may participate in the pathogenesis of airway inflammatory process of HACCP.They can be used as the indicators of pathogenetic condition and therapeutic effects.

关 键 词：肺疾病 阻塞性 肺心病 白介素-4 白介素-8 高原 

分 类 号：R541.5[医药卫生—心血管疾病]