对比增强MR血管成像验证兔动脉硬化模型  

Contrast enhanced MR angiography for verification of atherosclerosis in rabbit models

作　　者：马小龙[1] 陆建平[1] 金爱国[1] 王莉[1] 刘崎[1] 汪建华[1] 

机构地区：[1]第二军医大学附属长海医院影像医学科,上海200433

出　　处：《中国医学影像技术》2010年第2期213-216,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨使用透视触发技术配合对比增强MR血管成像(CE-MRA)验证兔动脉硬化模型的可行性。方法成年新西兰雌性大白兔24只,采用高脂饲料喂养8周。喂养前、后采用透视触发技术配合1.5TMR对实验兔全身动脉行CE-MRA检查。实验1周后观察兔存活状态,将图像显示有斑块分布且狭窄程度超过管腔50%的血管段取出、切片、染色,再与MRA图像相对照。结果所有实验兔均无意外死亡发生。高脂喂养前MRA图像均显示血管壁光滑,管腔均匀。高脂喂养后MRA图像显示动脉内壁凹凸不平,其中32条颈总动脉、10条肠系膜上动脉、36条肾动脉局部管腔狭窄在50%以上;病理切片显示取材血管100%具有不同程度的硬化斑块,但与血管标本管腔狭窄程度相比,26.92%CE-MRA图像存在夸大,但程度不超过25%。结论Care-bolus配合CE-MRA验证兔动脉硬化模型具有可靠、创伤小、动物存活率高等优点。Objective To explore the feasibility of contrast enhanced-MRA （CE-MRA） in testifying atherosclerosis model of rabbits with Care-bolus. Methods A total of 24 female New Zealand rabbits were fed with high cholesterol diet for 8 weeks. The whole body arteries of rabbits were inspeeted with CE-MRA and Care-bolus technology at 1.5T MR scanner before and after high cholesterol diet, and the images were compared accordingly. The survival conditions of rabbits were observed 1 week after scanning, and then the arteries with appeared plaques and angiostegnosis level more than 50% were taken out, sliced and dyed. Results No rabbit died unexpectedly during the study. Before feeding with high cholesterol diet, the arteries were smooth and lumens uniformity. After feeding high cholesterol diet, the inner walls of all aorta became rugose. The lumen stenosis of 32 common carotid arteries, 10 superior mesenteric arteries and 36 renal arteries were more than 50%. Pathological slices showed that 100% vessel had plaques. Compared with pathological findings, CE-MRA exaggerated lumen stenosis level in 26.92%, but no more than 25%. Conclusion To testify atherosclerosis model of rabbits using CE- MRA with Care-blous technology is reliable, causing tiny trauma and good at animal survival rate.

关 键 词：模型 动物 动脉硬化 磁共振血管成像 兔 

分 类 号：R445.2[医药卫生—影像医学与核医学] R-332[医药卫生—诊断学]