不同氧流量对七氟醚排出的影响及与苏醒的关系  

The Influence of Different Oxygen Flows on Exhausting Dynamics of Sevoflurane and Awakening Process

作　　者：毛卫克[1] 姚尚龙[1] 王明玲[1] 王学仁[1] 

机构地区：[1]同济医科大学附属协和医院麻醉学教研室

出　　处：《临床麻醉学杂志》1998年第6期342-344,共3页Journal of Clinical Anesthesiology

摘　　要：目的：研究停吸七氟醚后环路内给不同氧流量对其肺泡排出过程的影响及其与苏醒的关系。方法：２８例择期手术病人随机分为：Ⅰ组（ｎ＝８），停吸七氟醚后给Ｏ２２Ｌ／ｍｉｎ；Ⅱ组（ｎ＝１０）、Ⅲ组（ｎ＝１０）则分别给Ｏ２４Ｌ／ｍｉｎ和６Ｌ／ｍｉｎ。结果：三组七氟醚呼末浓度／停吸前呼末浓度（ＦＡ／ＦＡＯ）随时间的曲线经拟合符合对数方程式ＬｇＦＡ／ＦＡＯ＝Ａ±Ｂｔ，经计算七氟醚呼末浓度降低５０％（ＦＡ／ＦＡＯ＝０．５）、降低８０％（ＦＡ／ＦＡＯ＝０．２）和降低９０％（ＦＡ／ＦＡＯ＝０．１）的时间以Ⅲ组最快，Ⅱ组次之，Ⅰ组最慢（组间Ｐ＜０．０１）。在停吸２０ｍｉｎ内患者出现肢动、睁眼的时间快慢以Ⅲ组＞Ⅱ组＞Ⅰ组，但肢动、睁眼时呼末七氟醚浓度三组间无显著差异（Ｐ＞０．０５）。结论：停吸七氟醚后随氧流量增加，七氟醚排出显著加快，苏醒时间亦明显缩短。Objective: The pulmonary expelling dynamics of sevoflurane and its relation to awakening response at different O 2 flows were investigated after anesthesia. Methods: 28 adult surgical patients were assigned randomly to three groups: group Ⅰ ( n= 8), O 2=2L/min, group Ⅱ ( n= 10), O 2=4L/min and group Ⅲ ( n= 10), O 2=6L/min. Results: The curve of end tidal concentration (F A/F AO ) time of sevoflurane could be best fitted to a logarithmic equation: Lg(F A/F AO )=A±Bt, 0<t≤20min. The time course when the F A of sevoflurane decreased by 50% (F A/F AO =0.5), by 80% (F A/F AO =0.2) and by 90% (F A/F AO =0.1) was as follows: groupⅢ<groupⅡ<groupⅠ ( P< 0.01). Although the time when patients moved and eye opened during awakening process was shorter in groupⅢ than that in groupⅡ and groupⅠ, the related sevoflurane concentration at the appearence of movement and eye open failed to show any significant difference between groups ( P> 0.05). Conclusion: The process of sevoflurane expelled from the lungs can be speeded up significantly as O 2 flow increased after anesthesia, meanwhile the awakening time can be shortened as well.

关 键 词：氧流量 七氟醚 苏醒 麻醉 

分 类 号：R614.1[医药卫生—麻醉学] R971.2[医药卫生—外科学]