体外受精-胚胎移植中影响临床妊娠的因素——附559个周期分析  

Factors Affecting the Clinical Pregnancy Rate in an In Vitro Fertilization and Embryo Transfer Program

作　　者：张丽珠[1] 魏志新[1] 刘平 陈贵安[1] 李美芝[1] 张菊 宋伟 

机构地区：[1]北京医科大学第三医院

出　　处：《中华妇产科杂志》1998年第12期727-730,共4页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的探讨体外受精胚胎移植（ＩＶＦＥＴ）中影响临床妊娠率的因素。方法对１９９２年至１９９５年１１月因双侧输卵管梗阻而行ＩＶＦＥＴ的５５９个周期的资料进行回顾性分析，应用计算机ＳＰＳＰＣＶ３０系统，进行单因素变异方差分析。结果５９个周期总临床妊娠率为２１６％。结核性输卵管梗阻占２８４％，继发不孕中３４９％有人工流产史。环境改变、阻塞原因不同及过去子宫内妊娠，不影响ＩＶＦＥＴ成功率。当移植胚胎数增加到５个时，临床妊娠率最高，为３２５％。累积胚胎评分或胚胎质量与临床妊娠率明显有关。结论移植胚胎数及其质量，是影响临床妊娠成功的重要因素，同时应注意预防高序多胎妊娠发生，并对胚胎存活潜力及子宫接受力作进一步研究。Objective To analyze the various factors in an in vitro fertilization and embryo transfer (IVF ET) program which may affect the clinical pregnancy rate. Methods A retrospective study was done on 559 IVF ET cycles from 1992～Nov. 1995. The indication for treatment was bilateral tubal blockage. The χ 2 analysis of single factor variants with SPSS PC+V3.0 was used for statistics.Results The overall clinical pregnancy rate in 559 cycles was 21.6%. The cause of tubal blockage due to tuberculoses consisted of 28.4%, and 34.9% of secondary sterility had the history of artificial abortion. The changes of environment, the different causes of tubal blockage, the history of previous intrauterine pregnancy did not affect the clinical pregnancy rate. When the number of embryos trans ferred increased to 5, the clinical pregnancy rate was highest 32.5%. The cumulative embryo score or embryo quality was related significantly with clinical pregnancy rate. Conclusions The number and quality of embryos transferred are important factors affecting the clinical pregnancy rate. However, measures to prevent high order multiple pregnancy and studies on the survival potential of embryos besides their morphology should be emphasized.

关 键 词：体外受精 胚胎移植 妊娠 影响因素 

分 类 号：R321－33[医药卫生—人体解剖和组织胚胎学]