大鼠脑损伤后血脑屏障变化的定量研究  

Quantitative study of blood-brain barrier permeability after brain injury in rats

作　　者：李良平[1] 徐如祥[1] 钟世镇[2] 

机构地区：[1]第一军医大学珠江医院神经外科,广州510282 [2]第一军医大学解剖学教研室,广州510515

出　　处：《第一军医大学学报》1998年第4期252-253,共2页Journal of First Military Medical University

基　　金：广东省自然科学基金

摘　　要：检测了156只雌性SD大鼠不同程度脑损伤后脑组织伊文氏兰含量，结果发现，脑损伤越重，血脑屏障破坏发生时间越早，且程度越重。此结果提示，脑损伤后脑组织伊文氏兰含量测定能定量评价血脑屏障损伤程度，为研究血脑屏障的通透性和药理保护性作用，提供了一种新的方法。This study examined Evans blue's dye content in brain tissue after mild,moderate and severe brain injuries in rats.The severity of blood-brain barrier's BBB disruption was consistent with the degree of brain injury. The more severe it is injury,the earilier the BBB disruption began. It was demonstrated that determination of Evens blue's content in the brain tissue after brain injury can quantitatively eva1uate the BBB disruption and provide a new method to study the BBB permeability and assess the BBB-protective properties of pharmacological agents

关 键 词：颅脑损伤 脑水肿 血脑屏障 伊文氏兰 大鼠 

分 类 号：R651.15[医药卫生—外科学]