注射用阿莫西林钠舒巴坦钠(4:1)与(2:1)药效学比较  

Comparative Studies on Pharmacodynamics of Amoxicillin Sodium and Sulbactam Sodium(4:1) and(2:1) for Injection

作　　者：王丹[1,2] 王秀英[1] 李平[1] 

机构地区：[1]辽宁省食品药品检验所,沈阳110023 [2]沈阳市药品检验所

出　　处：《中国药师》2010年第2期213-214,共2页China Pharmacist

摘　　要：目的:考察注射用阿莫西林钠舒巴坦钠[4:1,AMCL-SBT(4:1)]、注射用阿莫西林钠舒巴坦钠[2:1,AMCL-SBT(2:1)]的体内抗菌作用,比较2种受试物的半数有效量(ED_(50))。方法:分别以金黄色葡萄球菌(S.aureus)、肺炎克雷伯菌(K.pneumoniae)、大肠杆菌(E.coli)作为感染菌对小鼠进行腹腔注射,对已感染的小鼠按不同组别分别静脉注射AMCL-SBT(4:1)和AMCL-SBT(2:1)各剂量,计算ED_(50)值。结果:AMCL-SBT(4:1)和AMCL-SBT(2:1)对S.aureus感染小鼠的ED_(50)分别为293.7和292.5 mg·kg^(-1),对K.pneumoniae感染小鼠的ED_(50)分别为293.1和271.0 mg·kg^(-1),对E.coli感染小鼠的ED_(50)分别为240.4和231.9 mg·kg^(-1)。其ED_(50)值经t检验比较,差别均无统计学意义(P>0.05)。结论:AMCL-SBT(4:1)和AMCL-SBT(2:1)对S.aureus、K、pneumoniae、E.coli感染的小鼠均有较好的保护作用,且体内的抗菌作用相当。Objective： To investigate the antibacterial in vivo test of amoxicillin sodium and sulbactam sodium for injection （4： 1, 2：1 ） ,and compared their EDs0 separately. Method： AMCL-SBT（4：1 ）and AMCL-SBT（ 2：1 ） were given intravenously respectively to the mice ,which systemically infected by S. aureus, K. pneumoniae and E. coli, then the EDso were calculated. Result： The ED50 of AMCL-SBT（4：1 ）and AMCL-SBT （2：1 ） against S. aureus were 293.7 and 292.5 mg.kg-1 respectively;The ED50 of them against K. pneumoniae were 293.1 and 271.0 mg.kg-1 respectively;The ED50 of them against E. coli were 240.4 and 231.9 mg-kg-l respectively. There was no significant difference in their ED50 （ P 〉 0.05 ）. Conclusion： AMCL-SBT （4：1 ） and AMCL-SBT （ 2：1 ） have relatively good protection to the mice provoked by S. aureus, K. pneurnoniae and E. coli, and the antibacterial activity in vivo of them are the same.

关 键 词：注射用阿莫西林钠舒巴坦钠(4:1) 体内抗菌作用 半数有效量 

分 类 号：R965.1[医药卫生—药理学]