改变血压波动性对靶器官损伤的影响  

Effects of changing blood pressure variability on target organs damage in spontaneously hypertensive rats

作　　者：刘建国[1] 龚侃[1] 程勇[1] 楚正绪[1] 苏定冯[1] 

机构地区：[1]第二军医大学基础医学部药理学教研室

出　　处：《第二军医大学学报》1998年第6期515-518,共4页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金

摘　　要：目的：用抗高血压药尼群地平（Ｎｉｔ）及肼屈嗪（Ｈｙｄ）研究血压波动性（ＢＰＶ）的改变与靶器官损伤（ＴＯＤ）的关系。方法：将自发性高血压大鼠（ＳＨＲ）随机分３组，一组为对照组，另两组分别用Ｎｉｔ及Ｈｙｄ治疗１６周。记录２４ｈ血压，计算出ＢＰＶ；取心、脑、肾和脾做大体标本，行光镜、电镜病理检查，参照ＴＯＤ半量化指标对损伤程度评分，所得分数与ＢＰＶ作相关性分析。结果：两个治疗组血压基本相近，比对照组明显下降；ＢＰＶ：Ｎｉｔ组＜对照组＜Ｈｙｄ组；ＴＯＤ：Ｎｉｔ组＜对照组＜Ｈｙｄ组；直线相关分析显示ＢＰＶ的大小与ＴＯＤ程度呈正相关。结论：（１）ＢＰＶ与ＴＯＤ之间呈正相关，降低ＢＰＶ对靶器官有保护作用；（２）抗高血压治疗时，为了减轻ＴＯＤ程度，在降低血压的同时，应考虑降低ＢＰＶ。Objective: To study the relationship between blood pressure variability (BPV) and target organs damage (TOD) in spontaneously hypertensive rats (SHR) by two antihypertensive drugs, nitrendipine (Nit) and hydralazine (Hyd). Methods: The rats were divided into control group, Nit group and Hyd group. After 16 weeks, intra arterial blood pressure was continuously recorded for 24 h in freely moving rats by micro computer system. BPV was characterized by standard deviation. After two days, serum creatinine and blood urea nitrogen were determined and the sections of cerebra, heart, kidney and spleen stained with the special methods to assess the severity of TOD. According to predetermined criteria, each animal gained its score.With this score,the relationship between BPV and TOD was analyzed. Results: The average BP of the two drug therapy groups reduced about 7.3 kPa compared with that of control group (P<0.001). But BPV and TOD were Nit group <control group<Hyd group, respectively. Conclusion: (1) There is positive correlation between BPV and TOD. Lower BPV in SHR is beneficial to protection of target organs.(2)For reducing the severity of TOD, the doctors not only consider how to decrease BP, but also consider how to decrease BPV when they select the antihypertensive drugs to treat hypertensive patients.

关 键 词：血压波动性 靶器官损伤 高血压 TOD 降压药 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]