三种去神经法对清醒大鼠动脉压力感受性反射功能的影响  

Effects of different baro denervations on arterial baroreflex function in conscious rats

作　　者：刘卫[1,2] 殷明[1,2] 苏定冯[1,2] 

机构地区：[1]第二军医大学基础医学部药理学教研室 [2]第二军医大学药学院药理学教研室

出　　处：《第二军医大学学报》1998年第6期542-544,共3页Academic Journal of Second Military Medical University

摘　　要：目的：测定急、慢性去主动脉神经（ＡＤ）、去颈动脉窦神经（ＳＤ）、同时去主动脉和窦神经（ＳＡＤ）后大鼠动脉压力感受性反射对血压控制（ＡＢＲ－ＢＰ）和心动周期控制（ＡＢＲ－ＨＰ）的影响。方法：测定ＡＢＲ－ＢＰ采用阻断动脉压力感受性反射传出通路前后，比较机体对去氧肾上腺素升压反应面积差异的方法，所得数值与改良的Ｓｍｙｔｈ方法测定的ＡＢＲ－ＨＰ值进行比较。结果：（１）大鼠ＳＡＤ后ＡＢＲ－ＨＰ为零，且代偿不明显；而ＡＢＲ－ＢＰ约为３０％，且代偿明显；（２）ＳＤ后ＡＢＲ－ＢＰ与ＡＢＲ－ＨＰ无显著差异，而ＡＤ和ＳＡＤ后ＡＢＲ－ＢＰ的作用显著大于ＡＢＲ－ＨＰ的作用。结论：（１）大鼠的ＡＢＲ－ＨＰ传入冲动全部来自于主动脉弓和颈动脉窦的压力感受器，而ＡＢＲ－ＢＰ传入冲动大部分来自于这两处的感受器；（２）主动脉神经和窦神经感受传入在ＡＢＲ－ＢＰ中的作用是相当的，并有明显的相互代偿；而在ＡＢＲ－ＨＰ中，主动脉神经的作用比窦神经重要，其代偿能力也比窦神经显著。Objective: To observe the effects of acute and chronic aortic denervation (AD), sinus denervation (SD) and sinoaortic denervation (SAD) on arterial baroreflex control of blood pressure (ABR BP) and arterial baroreflex control of heart period (ABR HP) in SD rats. Methods: ABR BP was measured by means of comparing the response to intravenous phenylephrine before and after the ABR efferent blockade, and the result was compared with that obtained by the modified Smyths method which measures ABR HP. Results: (1) ABR HP was zero after SAD, and its compensatory function was not evident; ABR BP was about 30%, and its compensatory function was significant. (2) There was not significant difference between ABR HP and ABR BP after SD, but the effect of ABR BP was greater than that of ABR HP after AD or SAD. Conclusion: (1) ABR HP in rats is completely dependent on the input from aortic and carotid baroreceptors, while ABR BP is mostly dependent on them. (2) The importance of the aortic nerve is matched for that of sinus nerves in ABR BP, and they can compensate for each other. But as for ABR HP, the role of aortic nerve and their compensatory potency are more important than that of sinus nerves.

关 键 词：心血管 调节 ABR AD SD SAD 

分 类 号：R331.36[医药卫生—人体生理学]