高危型HPV检测在预测宫颈上皮内瘤变锥切后残存病变或复发中的意义  

Significance of high risk HPV detection in predicting residual disease or recurrence after cervical conization for cervical intraepithelial neoplasia

作　　者：蒋学锋[1] 杨洁[1] 阚淳一[1] 张逸群[1] 叶双梅[1] 夏曦[1] 李科珍[1] 卢运萍[1] 马丁[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤生物医学中心,湖北武汉430030

出　　处：《中国妇幼保健》2010年第6期745-748,共4页Maternal and Child Health Care of China

基　　金：国家重大"973"计划项目〔2009CB521808〕

摘　　要：目的:评价高危型HPV(HR-HPV)检测在预测宫颈上皮内瘤变宫颈锥切术后残存病变或复发中的意义。方法:收集2004年4月1日～2009年5月30日武汉同济医院妇产科因宫颈上皮内瘤变行二次手术治疗的44例病人的临床资料进行回顾性研究,所有病人均于首次宫颈手术前6个月内进行了HR-HPV检查。结果:Logistic回归模型分析显示,患者年龄、产次、锥切方法、腺体是否累及和CIN病变程度与宫颈锥切后病人是否发生残存病变或复发无关,而HR-HPV测量值(RLU/PC)≥500是宫颈锥切术后发生残存病变或复发的高危因素。结论:HR-HPV检测是一种有效地预测宫颈锥切术后残存病变发生或复发的方法,对子宫颈疾病的诊疗具有重要的意义。Objective： To evaluate the significance of high risk HPV （HR -HPV） detection in predicting residual disease or recurrence alter cervical conization for cervical intraepithelial neoplasia （CIN） . Methods： Clinical data of 44 patients undergoing second operation of CIN from April 1,2004 to May 30, 2009 were analyzed retrospectively, and all the patients accepted HR - HPV detection within six months before first operation. Results： Logistic regressive model analysis showed that there was no correlation between age, times of delivery, modes of cervical eonization, glands involvement or not, lesion degrees of CIN and residual disease/recurrence or not after cervical conizatian, the value of HR - HPV ≥ 500 was a high risk factor for residual disease or recurrence. Conclusion： HR - HPV detection is an effective method to predict residual disease or recurrence after cervical eonization for CIN, which plays an important role in diagnosis and treatment of cervical diseases.

关 键 词：HR—HPV检测 宫颈上皮内瘤变 宫颈锥切 残存病变 复发 

分 类 号：R713.4[医药卫生—妇产科学]