戊肝患者及其密切接触者血清标志物检测结果分析  

ANALYSIS OF RESULTS ON DETECTING SERUM MARKERS OF 94 HEPATITIS E PATIENTS AND THEIR CONTROL

作　　者：何义林[1] 罗锋[1] 马智龙[1] 曹淑清[1] 张俊岭[1] 陆祥彬[1] 

机构地区：[1]江苏泰州市疾病预防控制中心,泰州225300

出　　处：《现代预防医学》2010年第4期761-762,共2页Modern Preventive Medicine

基　　金：江苏省卫生厅预防医学科研课题(Y200716);泰州市社会发展计划项目(2007137)

摘　　要：[目的]探讨戊肝患者及其密切接触者血清抗体的携带现状以及HEV与HBV重叠感染状况。[方法]用酶联免疫吸附试验(ELISA)法对94例戊肝患者及其密切接触者人群血清标本开展抗HAV-IgM、HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc、抗-HCV、抗HEV-IgM、抗HEV-IgG检测,对两组研究对象实验室检测结果用χ2检验进行统计分析。[结果]病例组抗HEV-IgM和抗HEV-IgG阳性率分别为27.66%和89.36%,密切接触者组抗HEV-IgM和抗HEV-IgG阳性率分别为4.94%和64.20%,两组人群抗HEV-IgM和抗HEV-IgG阳性率差异有统计学意义(P﹤0.01)。病例组与密切接触者组伴HBV感染率分别为34.04%和30.86%,差异无统计学意义(χ2=0.20,P=0.65)。[结论]戊肝密切接触者有较高的抗HEV-IgM和抗HEV-IgG阳性率,戊肝患者与密切接触者人群相比未显示出较高的HBV感染率。[Objective] To observe the serum markers of hepatitis E and co-infection state of hepatitis E virus （HEV） with hepatitis B virus （HBV） among hepatitis E patients and their Control. [Methods] The blood of each case were collected to detect the anti-HAV IgM, HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc, anti-HCV, anti-HEV IgM and anti-HEV IgG by using ELISA. Chi-test was used to compare the results of the detection between hepatitis E patients and their Control [Results] The positive rates of anti-HEV IgM and anti-HEV IgG in the patients were 27.66% and 89.36%, respectively, and were 4.94% and 64.20% in the controls. There was significant difference between hepatitis E patients and their controls inthe positive rates of anti-HEV IgM and anti-HEV IgG （P 〈 0.01）. The co-infection rates of HEV with HBV were 34.04% and 30.86% among the patients and the control （Х^2 = 0.20, P = 0.65）. [Conclusion] There was a high positive rate of anti-HEV IgM and anti-HEV IgG among intimate contact of hepatitis E patients. There was no difference in the co-infection rates of HEV with HBV between hepatitis E patients and the controls.

关 键 词：戊型肝炎 患者 密切接触者 血清标志物 

分 类 号：R512.6[医药卫生—内科学]