子宫内膜异位症与肿瘤坏死因子TNFα-308G/A和TNFβG252A基因多态性的关系  

Study on TNFα-308G/A and TNFβG252A polymorphisnis in patients with endometriosis

作　　者：车坤兰[1] 罗程[2] 何凤仪[1] 谭淑娴[1] 曾改鸿[3] 陈盛强[1] 

机构地区：[1]广州医学院第二附属医院,广东广州510260 [2]广州市番禺中心医院,广州511400 [3]深圳保安区人民医院,深圳510260

出　　处：《解剖学研究》2010年第1期21-24,共4页Anatomy Research

基　　金：广东省卫生科技项目(A2009270)

摘　　要：目的探讨肿瘤坏死因子TNFα-308G/A和TNFβG252A基因多态性与子宫内膜异位症的关系。方法运用多聚酶链反应技术检测100例子宫内膜异位症及100例正常人肿瘤坏死因子TNFα-308G/A和TNFβG252A基因多态性。结果TNFα-308G/A和TNFβG252A各种基因型频率在患者组与正常对照组之间的差异无统计学意义(P>0.05)。结论肿瘤坏死因子TNFα-308G/A和TNFβG252A基因多态性与子宫内膜异位症无明显相关。Objective To investigate the relationship between tumor necrosis factor（TNF） polymorphism and endometriosis＇s disease. Methods The polymorphism of TNFα-308G/A and TNFβG252A was screened by PCR-RELP. Results There were no significant differences in the frequencies of TNFα-308G/A and TNFβG252A gene between the patients and control group （P〉 0.05）. Conclusion No evident association is found between TNFα-308G/A, TNFβG252A polymorphism and endometriosis.

关 键 词：子宫内膜异位症 肿瘤坏死因子α、β 基因多态性 

分 类 号：R711.71[医药卫生—妇产科学] R392-33[医药卫生—临床医学]