异丙酚对重症急性胰腺炎大鼠早期肺损伤的干预作用  

Effect of propofol on pulmonary injury induced by early-stage severe acute pancreatitis in rats

作　　者：张义胜[1] 王明海[1] 陶坤[1] 陈方正[1] 赵国海[1] 

机构地区：[1]皖南医学院附属弋矶山医院普外四科

出　　处：《中国临床药理学与治疗学》2009年第11期1208-1211,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：安徽省教育厅自然科学研究基金项目(2004kj346)

摘　　要：目的:探讨异丙酚对重症急性胰腺炎(SAP)大鼠早期肺组织损伤的干预作用。方法:健康成年雄性SD大鼠72只,按随机化原则分成9组,每组8只。即假手术组,重症急性胰腺炎30、60、120、360min组(SAP组:胰胆管逆行注入质量分数为5%牛磺胆酸钠溶液)和异丙酚30、60、120、360min组(造模后立即给予异丙酚150μg·kg-1.min-1尾静脉持续注射)。剖杀各组大鼠,分别检测血清淀粉酶(AMY)、脂肪酶(LIP)的含量,计算肺、胰腺组织湿/干重比,并观察胰腺组织和肺组织的病理学改变。结果:异丙酚组大鼠360min时肺组织含水量明显减轻、病理积分明显降低(P均<0.01),但大鼠胰腺组织含水量及病理积分无明显改变(P均>0.05)。结论:异丙酚可减轻重症急性胰腺炎大鼠早期肺组织的损伤程度,但不能减轻重症急性胰腺炎大鼠早期胰腺组织的损伤程度。AIM： To investigate whether propofol can alter the pulmonary inflammation induced by severe acute pancreatitis（SAP） in rats during its early period. METHODS： Seventy-two adult male Sprague-Dawley （SD）rats were randomly divided into nine groups with 8 animals in each group： sham group, SAP 30, 60, 120, 360 min groups and propofol treatment 30, 60, 120,360 min groups. The preparation of SAP were induced by retrograde injection of 5% sodium tauro- eholate into the pancreatic duct of rats. And the treatment groups received propofol with doses of 150 μg·kg- 1·min^-1 injected continually immediately in vena caudalis after the preparation of ASP were made. Rats were sacrificed at different time points, and the level of AMY and LIP, the wet dry weight ratio（W/D） of pulmonary and pancreatic tissue, the pathological change of pulmonary and pancreatic tissue were exam- ined. RESULTS：Water content and pathological score of pulmonary tissue were decreased significantly within 360 minutes after reproduction of SAP were received propofol（both P 〈 0.01）. But no obvious change was observed in water content and pathological score of pancreatitis tissue（both P 〉 0.05）. CONCLUSION： propofol can alleviate pulmonary inflammation induced by severe acute pancreatitis in its early period. But propofol can not alleviate the injury of pancreatitis tissue.

关 键 词：异丙酚 胰腺炎 急性 重症 肺损伤 炎症 

分 类 号：R965.2[医药卫生—药理学]