男性慢性盆腔疼痛综合征患者前列腺液中肿瘤坏死因子受体浓度测定  

Concentrations of tumor necrosis factor receptors at prostatic secretion in male patients with chronic pelvic pain syndrome

作　　者：陈荣生[1] 罗冬娇[2] 陈立[1] 童夏生[3] 陈豪[4] 王恩智[5] 

机构地区：[1]台州市中西医结合医院泌尿外科,附属浙江中医药大学第一临床医学 [2]杭州师范大学钱江学院医学系 [3]台州市中西医结合医院儿科,附属浙江中医药大学第一临床医学 [4]台州市中西医结合医院病理科 [5]台州市中西医结合医院检验科

出　　处：《中国临床药理学与治疗学》2009年第11期1304-1307,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:检测肿瘤坏死因子受体(sTNF-R1和sTNF-R2)在男性慢性盆腔疼痛综合征(CPPS)患者前列腺液中的表达水平,探讨sTNF-R1和sTNF-R2在CPPS炎症过程中的可能作用机制。方法:CPPS患者均来自2008年3月-2009年1月,其中ⅢA级24例、ⅢB级20例,并与15例健康人作对照。直肠按摩取出前列腺液,ELISA法检测前列腺液sTNF-R1和sTNF-R2的蛋白浓度。结果:CPPSⅢA组前列腺液sTNF-R1和sTNF-R2的蛋白浓度显著高于ⅢB组[(46±6vs41±6),P<0.05;(13.0±4.8vs7.9±4.1)ng/mL,P<0.01],且ⅢB组前列腺液sTNF-R1和sTNF-R2的蛋白浓度显著高于对照组[分别为(25±8)、(2.5±1.9)ng/mL,均P<0.01]。结论:男性CPPS患者前列腺液中sTNF-R1和sTNF-R2的蛋白浓度增加,两者可能共同参与了CPPS的炎症过程。AIM： To detect the concentrations of solube tumor necrosis factor receptors （sTNF-R1 and sTNF-R2） at prostatic secretion in male patients with chronic pelvic pain syndrome（CPPS）. And to investigate the potential roles of sTNF-R1 and sTNF-R2 in the development of CPPS inflammation. METHODS： All the patients were obtained during March 2008 to Janua- ry 2009 including 24 cases of CPPS m A and 20 cases of CPPS m B, and were compared to 24 cases of volunteers. Expressed prostatic secretion were obtained by rectum massage methods. Concentrations of sTNF-R1 and sTNF-R2 were measured by enzyme linked immu- nosorbent assay methods. RESULTS： The concentrations of sTNF-R1 and sTNF-R2 proteins were signifi- cantly higher from CPPS Ⅲ A group than those from CPPS m B group [（46 ±6 vs 41 ± 6）, P 〈 0.05,（13.0±4.8 vs 7.9 ± 4.1） ng/mL, P 〈 0.01], and they were dramaticly higher from CPPS m B group than those from compared group [ （25 ± 8）, （2.5 ± 1.9） ng/mL,all P 〈 0.013. CONCLUSION： Concentrations of sTNF-R1 and sTNF-R2 proteins are increased in male patients with CPPS. Both of them may be associated with the development of CPPS inflammation.

关 键 词：慢性盆腔疼痛综合征 肿瘤坏死因子 受体 酶联免疫吸附试验 

分 类 号：R69[医药卫生—泌尿科学]