生长发育期光照改变对成年大鼠抑郁相关行为的影响  

The effect of altered lighting hours in the rats of growth and development on depression-related behaviors in adult rats

作　　者：王丽娜[1] 张桂红[1] 樊红琨[1] 王书春[1] 乔鹏[1] 冯平福[1,2] 

机构地区：[1]郑州大学基础医学院生理教研室,河南郑州450052 [2]Case Western Reserve大学医学系呼吸,急诊与睡眠医学科,美国俄亥俄州克里夫兰44106

出　　处：《河南医学研究》2009年第4期294-298,共5页Henan Medical Research

摘　　要：目的:新近的研究发现光照时间延长会减少大鼠的自主运动,而运动具有全面抗抑郁的特点,因此我们想探讨光照时间的改变对大鼠抑郁相关行为的影响。方法:将50只5 w龄SD雄性大鼠随机分为5组,给予8 w延长、正常和缩短每日光照时间的处理,然后予以正常光照1 w。在光照恢复前和恢复后,用强迫游泳实验和Y-迷宫实验分别测试大鼠的抑郁相关行为和学习记忆能力。结果:延长光照时间使大鼠运动(攀爬+游泳)时间缩短,不动时间延长,学习和记忆的总次数、错误次数以及所花的总时间均显著增多;反之亦然。而且,此改变在恢复正常光照1 w后虽有所恢复,但均未回复到正常水平。结论:光照时间的改变可以影响大鼠在强迫游泳实验和Y-迷宫实验中的心理抑郁程度和学习记忆能力,且不会因短期的正常光照而消除。Objective： It is said that shorter daily lighting time and longer lighting time would affect Hamsters＇ depressive measurements in behavioral test,and we also would like to determine how the time affect rats＇ depressive measurements.Methods： Fifty 5-week-old male Sprague-Dawley（SD） rats were divided into five groups.Before these groups were treated with normal lighting hours for one week,they were treated with different daily lighting hours for eight weeks..Before and after the light reverted,determining their depression degree through forced swimming test and determining their learning and memory ability via Y-maze test.Results：Prolonging lighting hours made Rats＇ movement（climbling and swimming） time shorter and the immobility time longer,and the total frequency,the error frequency and the cumulative time in learning and memory all increased significantly,vice versa.And althrough these changes were reverted a little after normal lighting for a week,they can＇t revert to normal level.Conclusion： Prolonging lighting hours would cause depression-related behaviors such as less movements and descent of learning and memory ability in rats,which suggests that altered lighting hours is an important factor to affect rats＇ emotion,and the effects couldn＇t be eliminated by short normal lighting.

关 键 词：光照 强迫游泳实验 Y-迷宫实验 抑郁 

分 类 号：R3[医药卫生—基础医学]