强化胰岛素治疗对脓毒症病人肠黏膜通透性的影响  

Effects of intensive insulin therapy on the intestinal permeability in sepsis patients

作　　者：石斌[1] 郭鸿[1] 张斌[1] 尹超[1] 侯启亮[1] 曹永强[1] 文新忠[1] 

机构地区：[1]兰州大学第一医院ICU,甘肃兰州730001

出　　处：《肠外与肠内营养》2010年第1期11-12,16,共3页Parenteral & Enteral Nutrition

基　　金：甘肃省卫生厅“陇原青年创新人才扶持计划”资助[2008]93号

摘　　要：目的：探讨强化胰岛素治疗对脓毒症病人D-乳酸和二胺氧化酶（DAO）的影响,观察胰岛素对脓毒症病人肠黏膜通透性的作用。方法：将48例脓毒症病人随机分为治疗组和对照组。治疗组病人用胰岛素治疗,血糖严格控制在5.07.0 mmol/L。对照组病人常规治疗,血糖控制在10.011.9 mmol/L。于治疗前后检测血浆D-乳酸含量和DAO活性。结果：治疗后治疗组病人血浆D-乳酸水平和DAO活性明显低于对照组（P〈0.05）。结论：胰岛素能降低脓毒症病人肠道黏膜通透性,减少肠道细菌移位,改善肠功能障碍。Objective： To discuss the effect of intensive insulin therapy on D-lactic acid and diamine oxidase level in patients with sepsis.Methods： 48 patients was divided into control group and conventional group randomly.Content of D-lactic acid and diamine oxidase in serum was detected with absorption spectrometry before and after therapy.Result： D-lactic acid and diamine oxidase in patients decreased significantly in control group compared to that of conventional group.Conclusion： Insulin can depress interstinal permeability and ameliorate sepsis symptom resulted from bacterial translocation from intestine.

关 键 词：胰岛素 脓毒症 D-乳酸 二胺氧化酶 

分 类 号：R459.7[医药卫生—急诊医学]