胰岛素通过泛素系统对脓毒症病人骨骼肌代谢的调理作用  

Regulation effect of insulin on the hypermetabolism of the skeletal muscles of septic patients through ubiquitin-proteasome pathway

作　　者：陈启仪[1] 虞文魁[1] 李宁[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所,江苏南京210002

出　　处：《肠外与肠内营养》2010年第1期51-54,共4页Parenteral & Enteral Nutrition

基　　金：国家自然科学基金(30801086);江苏省自然科学基金(BK2007573);教育部博士点新教师基金(200802841005)资助

摘　　要：脓毒症病人中分解代谢增强现象极其普遍,尤以骨骼肌蛋白分解明显。泛素-蛋白酶体途径的激活为脓毒症病人骨骼肌蛋白分解的重要环节。其活性受炎性细胞因子和糖皮质激素等多因素影响。胰岛素在调理泛素-蛋白酶体途径的活性中起着重要的作用。以下就胰岛素通过泛素-蛋白酶体途径对脓毒症病人骨骼肌代谢的调理作用作一综述。Hypermetabolism syndrome,especially in skeletal muscles,is exceedingly common in septic patients.Many studies suggest that the activity of ubiquitin-proteasome pathway is a vital procedure for hypermetabolism of skeletal muscles of septic patients and its activation can be influenced by a variety of factors,such as proinflammatory cytokine and glucocorticoid,etc.Evidences indicate that insulin has played an important role in opsonizing the activation of ubiquitin-proteasome pathway.This paper reviews the regulation effect of insulin to the hypermetabolism of the skeletal muscles of septic patients through ubiquitin-proteasome pathway.

关 键 词：胰岛素 泛素-蛋白酶体途径 脓毒症 骨骼肌代谢调理 

分 类 号：R459.7[医药卫生—急诊医学]