基于三维重建技术及有限元分析的脊柱骨密度测量及其意义  

The measurement of bone density based on three-dimensional reconstruction and finite element analysis

作　　者：张国栋[1] 毛文玉[1] 廖维靖[1] 陈建桥[1] 栾夏刚[1] 郑晓晖[1] 陶圣祥[1] 

机构地区：[1]武汉大学中南医院康复医学科,武汉430071

出　　处：《中国临床解剖学杂志》2010年第1期78-84,共7页Chinese Journal of Clinical Anatomy

摘　　要：目的探讨基于三维重建技术及有限元分析的测量骨密度的方法。方法以1具脊柱标本(C3～L5)进行高速CT薄层扫描,在Mimics中进行每个椎体的三维重建,在Ansys中进行体网格划分,在Mimics中赋予10、400种材料属性,输出至Ansys计算骨骼中每一种材料属性的体单元的体积,根据CT扫描的Hu值与骨密度的经验公式,计算标本质量及密度,对照组以电子天平测量(C3～L5)的质量。进行统计学处理。结果(1)对照组、10种及400种材料属性组C3～L5的密度值分别为0.62±0.09、0.5813±0.0806、0.5813±0.0805g/cm3;(2)单因素方差分析:对照组与赋予10、400种材料属性各试验组比较的P值均大于0.1,试验组组别之间P=0.997。结论(1)本试验方法可定量测量骨骼密度及其密质骨及松质骨密度值;(2)赋予骨骼10种材料属性即可达到测量要求;(3)本试验为骨密度与有限元分析的统一作初步准备。Objective To explore a method for measuring bone density base on three-dimensional reconstruction and finite element analysis.Methods One spine specimen（C3～L5） were used for this experiment.It was treated with thin-slice high resolution CT scan and three-dimensional reconstruction in Mimics,volume meshing in Ansys,assigned with 10 and 400 kinds of material attributes Mimics,then exported to Ansys to calculate the volumes of the block elements of every type of material attributes.The mass and the density of the specimen could be harvested according to the empirical formula concerning the gray value and the bone mineral density.The mass of control group（C3～L5） was measured with an electronic balance.All results were statistically treated with one-way ANOVA.Results The apparent densities of C3～L5 of control group,group of 10 and 400 kinds of material attributes were 0.62±0.09,0.5813±0.0806 and 0.5813±0.0805 g/cm3 respectively.P value was more than 0.1 when the density of control group compared with that of experimental groups which were assigned with 10 and 400 kinds of material attributes,while it was 0.997 within experimental groups.Conclusions Firstly,this method was able to measure the mass and the bone density quantitatively,as well as that of compact bone and cancellated bone;Secondly,to assign 10 kinds of material attributes to three-dimensional model of spine could match the needs for measurements;Thirdly,our experience could be used as an initial preparation for the unification of bone mineral density and finite element analysis.

关 键 词：骨表观密度 脊柱 三维重建 有限元 骨质疏松症 

分 类 号：R318.01[医药卫生—生物医学工程]