红花提取物、羟基红花黄色素A在血瘀大鼠体内的药动学特征  

Pharmacokinetic character of safflor yellow extraction and hydroxysafflor yellow A in blood stasis rats

作　　者：乔逸[1] 杨志福[1] 奚苗苗[1] 田云[1] 贾艳艳[1] 杨静[1] 陈敏纯[1] 文爱东[1] 

机构地区：[1]第四军医大学西京医院药剂科,西安710033

出　　处：《中国临床药学杂志》2010年第1期22-25,共4页Chinese Journal of Clinical Pharmacy

基　　金：国家自然科学基金资助(30672662)

摘　　要：目的研究红花提取物和羟基红花黄色素A(HSYA)在血瘀大鼠体内的药动学特征。方法HPLC-UV法测定血瘀大鼠血浆中HSYA的血药浓度,应用DAS2.0求得药动学参数。结果红花提取物和HSYA在血瘀大鼠体内主要药动学参数t_(1/2)、ρ_(max)、t_(max)、AUC_(0→6h)和AUC_(0→∞)分别为(1.38±0.21)和(1.11±0.25)h,(8.05±0.57)和(8.36±1.09)mg·L^(-1),(0.75±0.00)和(1.19±0.55)h,(19.24±1.18)和(22.93±2.19)mg·h·L^(-1),(20.45±1.00)和(23.84±2.00)mg·h·L^(-1)。结论红花提取物在急性血瘀大鼠体内吸收比HSYA快,而代谢比HSYA慢,说明红花提取物中其他成分可以影响HSYA的吸收和代谢。AIM To study the pharmacokinetic character of safflor yellow extraction and hydroxysafflor yellow A （HSYA） in blood stasis rats. METHODS The concentrations of HSYA in plasma of blood stasis rats were analyzed by HPLC-UV method. The pharmacokinetic parameters were calculated by the software DAS 2.0. RESULTS The main pharmacokinetic parameterst1/2、ρmax、tmax、AUC0→6h and AuC0→∞of safflor yellow extraction and HSYA were （ 1.38 ±0.21）and （1.11 ±0.25）h, （8.05 ±0.57）and （8.36 ± 1.09）mg·L^-1, （0.75 ±0.00）and（ 1.19 ±0.55）h, （19.24 ±1.18） and （22.93± 2.19） mg· h·L^-1, （20.45± 1.00） and （23.84 ± 2.00） mg· h·L^-1, respectively. CONCLUSION The absorption of safflor yellow is faster than HSYA in acute rat model of blood stasis syndrome , but the metabolism of safflor yellow is evidently slower than HSYA in acute rat model of blood stasis syndrome , which shows that the absorption and metabolism of HSYA could be affected by some factors in sattlor yellow extraction.

关 键 词：红花提取物 羟基红花黄色素A 高效液相色谱-紫外法 血瘀大鼠 药动学 

分 类 号：R285[医药卫生—中药学]