因子分析法在高血压住院患者降压效果研究中的应用  

Application of factor analysis in the study of antihypertensive effect in inpatients with hypertension

作　　者：舒薇[1] 周剑斌[1] 

机构地区：[1]上海市闸北区中心医院药剂科,上海200070

出　　处：《中国临床药学杂志》2010年第1期26-29,共4页Chinese Journal of Clinical Pharmacy

摘　　要：目的利用因子分析方法研究高血压住院患者治疗强度与降压效果的关系,为高血压病的降压治疗提供参考,也为开发和利用药品处方数据库进行科学研究提供一种方法。方法调用本院用药数据库和住院病史,提取高血压住院患者用药记录和住院期间的收缩压和舒张压等信息,用因子分析法计算患者治疗强度,并用方差分析法比较不同治疗强度的降压效果。结果住院高血压患者的血压下降值随治疗强度增加而增加。结论利用临床诊疗信息和因子分析法研究患者治疗强度与降压效果的关系其结果有参考价值,这种方法在临床药学研究中的应用值得重视。AIM To develop a prescription database of medicines, and to study the relationship between treatment intensity and antihypertensive effects in inpafients with hypertension by using the factor analysis. METHODS The prescription records and the information such as systolic pressure and diastolic pressure and so on were collected from the medicine database of hospital and medical record profiles. The factor analysis was applied to ealeulate the treatment intensity for inpatients with hypertension. The antihypertensive effects in groups of the different treatment intensities were eompared by analysis of variance. RESULTS The antihypertensive effects of the inpatients with hypertension were related with the treatment intensity. The decrease in the blood pressure of the inpatients with hypertension inereased with the increasing of the treatment intensity. CONCLUSION It is proved valuable to study the relationship between treatment intensity and antihypertensive effects by using the medicine database of hospital and clinical medical data. Such results have reference value and ought to be paid more attraction.

关 键 词：药品处方数据库 治疗强度 降压效果 因子分析 方差分析法 

分 类 号：R544.1[医药卫生—心血管疾病]