扶桑花乙酸乙酯溶物(HR-3)对心血管活动影响的初探  

Study on Action of Ethyl Acetate Extract of Hibiscus rosa sinensis Flowers (HR 3) in Cardiovascular System

作　　者：江燕[1] 赵翠兰[1] 李开源 常征 黄超[1] 周铭东 

机构地区：[1]云南大学生物系

出　　处：《云南大学学报（自然科学版）》1998年第6期469-472,共4页Journal of Yunnan University(Natural Sciences Edition)

基　　金：云南省应用基础研究基金

摘　　要：初步观察了扶桑花乙酸乙酯溶物（ＨＲ３）的抗心肌缺氧作用及对动物血压和离体蛙心的影响．实验表明：①ＨＲ３可使ＩＣＲ小鼠的常压耐缺氧时间显著延长（Ｐ＜０．０１），该作用与心得安无明显差异；可以明显延长夹闭气管小鼠的心电消失时间和异丙肾上腺素处理的小鼠心肌耐缺氧时间，提示ＨＲ３能对抗心肌缺氧．②１００ｍｇ／ｋｇ以上的ＨＲ３能明显降低家兔的收缩压与舒张压，该降压作用不被阿托品阻断，但不影响心率．③ＨＲ３对离体蛙心的心率及振幅呈梯度抑制作用，且该作用是可逆的．提示ＨＲ３可能通过减弱心肌收缩力，而产生降压作用和对抗心肌缺氧．The present communication deals with the effect of ethyl acetate extract of Hibiscus rosa sinensis flowers (HR 3)on cardic hypoxia,blood pressure and heart contratility of frog in vitro.The results indicate:①HR 3 makes the time of hypoxia tolerance much longer in mice of normal and injecting isoprenaline.And it also increases the time of ECG disappear in mice whose trachea is blocked.②When the dose is 100mg/kg,HR 3 can decrease systolic pressure and diastolic pressure of rabbit.Atropine can not interrupt the action.But HR 3 does not affect the heart rate in rabbit.③HR 3 inhibits heart rate and heart contract amplitude of frog in vitro with the increase of dose,but the inhibition is reversible.The results suggested that HR 3 can depress blood pressure and myoardial oxygen consumption by inhibiting heart contractility.

关 键 词：扶桑花 乙酸乙酯溶物 心肌收缩力 心血管活动 

分 类 号：R259.4[医药卫生—中西医结合] R282.710.5[医药卫生—中医内科学]