引导性骨再生联合高能震波修复节段性骨缺损  

Repairing segmental bone defects with membrane-guided bone regeneration combined with high energy shock wave

作　　者：邹国耀[1] 张天宇[2] 张林[1] 唐志宏[1] 

机构地区：[1]桂林医学院附属医院骨科,541001 [2]桂林医学院附属医院泌尿外科,541001

出　　处：《江苏医药》2010年第2期190-192,共3页Jiangsu Medical Journal

基　　金：广西科学研究与技术开发资助项目(桂科基:0236069)

摘　　要：目的探讨膜引导性骨再生联合高能震波修复节段性骨缺损的成骨效能。方法实验兔40只均分为A、B两组,制造两侧桡骨中段10 mm的骨缺损。A组将16 mm×14 mm的硅胶膜卷曲缝成管状,套于一侧桡骨缺损区,于术后第3周用高能震波冲击处理骨缺损的两骨断端(A1组);另一侧桡骨骨缺损单纯于术后第3周用同等条件的高能震波冲击骨缺损的两骨断端(A2组)。B组一侧骨缺损将16 mm×14 mm的硅胶膜(Silastic)卷曲缝成管状,套于一侧桡骨缺损处(B1组);另一侧作为空白对照(B2组)。于术后第1,2,4,6,8,10,12周分别行双侧桡骨X射线检查。于术后第2,4,8,12周切取标本行组织学检查及成骨面积分析。结果A1组疗效最好,B1组、A2组次之,B2组最差。结论膜引导性骨再生联合高能震波具有良好的成骨作用,可有效促进骨缺损的修复。Objective To investigate the osteogenic effect of combined use of membrane-guided bone regeneration and high energy shock wave（HESW） for repairing segmental bone defects.MethodsFourty rabbits were randomized into groups of A and B with 20 rabbits each.A 10 mm segmental bone defect of the radios on both sides was produced in both groups.In group A,a silastic membrane sized 16 mm×14 mm was crimped as fistuliform and was sheathed on one side of the bone defect treated with HESW at the both ends of the defects on the 3rd week after operation（group A1）,and the segmental bone defect on the other side was treated with HESW alone（group A2）.In group B,a silastic membrane sized 16 mm×14 mm was crimped as fistuliform and sheathed on one side of the bone defect（group B1） and the bone defect on the other side was not treated as the control（B2）.The X-ray examinations were done on the 1st,2nd,4th,6th 8th,10th and 12th postoperative week.Analysis of pathology and the area of new bone was performed on the 2nd,4th,8th and 12th postoperative week.Results The efficacy of treatment was in an order of group A1groups of B1 and A2group B2.Conclusion Membrane-guided bone regeneration combined with HESW has better osteogenic effect and can efficiently repair bone defects.

关 键 词：引导性骨再生 高能震波 骨缺损 

分 类 号：R684[医药卫生—骨科学]