基于金纳米颗粒的CT造影剂  

Contrast Agents for Computed Tomography Based on Gold Nanoparticles

作　　者：范旭[1,2,3,4] 郭志睿[5] 曹敏[3] 周雪锋[1,2] 顾宁[1,2,3,4] 

机构地区：[1]东南大学苏州研究院,苏州215123 [2]东南大学苏州市生物医用材料与技术重点实验室,苏州215123 [3]东南大学生物电子学国家重点实验室,南京210096 [4]东南大学江苏省生物材料与器件重点实验室,南京210009 [5]南京医科大学第一附属医院心血管病研究所,南京210029

出　　处：《CT理论与应用研究（中英文）》2009年第4期15-25,共11页Computerized Tomography Theory and Applications

基　　金：国家重点基础研究发展计划(973计划)子课题(2006CB933206)

摘　　要：金纳米颗粒有着优异的表面性质,成熟的制备路线和良好的生物相容性。目前临床通常使用的CT商用造影剂是含碘的有机分子。金与碘相比,有着更高的原子序数和X射线吸收系数。随着纳米材料和生物纳米技术的发展,近年来,在金纳米颗粒作为CT造影剂方面涌现出一系列优秀的工作成果。本文综述了金纳米颗粒的制备路线,表面修饰,以及X射线造影情况,重点介绍包裹了PEG、阿拉伯树胶、钆螯合物、高密度脂蛋白等的金纳米颗粒CT造影剂的试用情况,并对金纳米棒颗粒用作CT造影剂存在的问题和应用前景进行讨论。Gold nanoparticles hold excellent surface properties, multiple synthestic routes and good biocompatibility. Currently, the commercial clinical Computed Tomography（CT） contrast agents are iodine based organic molecules. Compared with iodine, Gold has a larger atomic number and X-ray absorption coefficient. In recent years, quite a few works about using gold nanoparticles as CT contrast agents have been published. In this review, We outlined the synthesis routes, surface modification, and the behaviors of gold nanoparticles as CT contrast agents. We emphasized the tryout of PEG gum arabic, gadolinium chelate, and high-density lipoproteins etc. as surfactant to coat gold nanoparticles for CT imaging. We also discussed the existent problems of the newly developed contrast agents and looked forward to the future of them.

关 键 词：金纳米颗粒 CT 造影剂 

分 类 号：TQ421.7[化学工程]